| Title |
Degradable gene delivery systems based on Pluronics-modified low-molecular-weight polyethylenimine: preparation, characterization, intracellular trafficking, and cellular distribution
|
|---|---|
| Published in |
International Journal of Nanomedicine, February 2012
|
| DOI | 10.2147/ijn.s27117 |
| Pubmed ID | |
| Authors |
Wei Fan, Xin Wu, Baoyue Ding, Jing Gao, Zhen Cai, Wei Zhang, Dongfeng Yin, Xiang Wang, Quangang Zhu, Jiyong Liu, Xueying Ding, Shen Gao |
| Abstract |
Cationic copolymers consisting of polycations linked to nonionic amphiphilic block polymers have been evaluated as nonviral gene delivery systems, and a large number of different polymers and copolymers of linear, branched, and dendrimeric architectures have been tested in terms of their suitability and efficacy for in vitro and in vivo transfection. However, the discovery of new potent materials still largely relies on empiric approaches rather than a rational design. The authors investigated the relationship between the polymers' structures and their biological performance, including DNA compaction, toxicity, transfection efficiency, and the effect of cellular uptake. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 26% |
| Researcher | 8 | 23% |
| Student > Master | 4 | 11% |
| Student > Doctoral Student | 3 | 9% |
| Student > Bachelor | 3 | 9% |
| Other | 2 | 6% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 14% |
| Biochemistry, Genetics and Molecular Biology | 5 | 14% |
| Chemistry | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
| Engineering | 3 | 9% |
| Other | 7 | 20% |
| Unknown | 8 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2012.
All research outputs
#17,438,425
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#2,461
of 4,077 outputs
Outputs of similar age
#173,824
of 254,308 outputs
Outputs of similar age from International Journal of Nanomedicine
#52
of 77 outputs
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So far Altmetric has tracked 4,077 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
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