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Barrier effect of Esoxx® on esophageal mucosal damage: experimental study on ex-vivo swine model

Overview of attention for article published in Clinical and Experimental Gastroenterology, June 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#19 of 293)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
2 tweeters
facebook
1 Facebook page
wikipedia
5 Wikipedia pages

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
31 Mendeley
Title
Barrier effect of Esoxx® on esophageal mucosal damage: experimental study on ex-vivo swine model
Published in
Clinical and Experimental Gastroenterology, June 2012
DOI 10.2147/ceg.s31404
Pubmed ID
Authors

Massimo Di Simone, Fabio Baldi, Valentina Vasina, Maria Laura Bacci, Fabrizio Scorrano, Gilberto Poggioli, Antonella Ferrieri

Abstract

The aim of the present study was to assess the potential barrier effect of Esoxx(®), a new nonprescription medication under development for the relief of gastroesophageal reflux symptoms. Esoxx is based on a mixture of hyaluronic acid and chondroitin sulfate in a bioadhesive suspension of Lutrol(®) F 127 polymer (poloxamer 407) which facilitates the product adhesion on the esophageal mucosa. The mucosal damage was induced by 15 to 90 minutes of perfusion with an acidic solution (HCl, pH 1.47) with or without pepsin (2000 U/mL, acidified to pH 2; Sigma-Aldrich). Mucosal esophageal specimens were histologically evaluated and Evans blue dye solution was used to assess the permeability of the swine mucosa after the chemical injury. The results show that: (1) esophageal mucosal damage is related to the perfusion time and to the presence of pepsin, (2) mucosal damage is associated with an increased permeability, documented by an evident Evans blue staining, (3) perfusion with Esoxx is able to reduce the permeability of the injured mucosa, even after saline washing of the swine esophagus. These preliminary results support further clinical studies of Esoxx in the topical treatment of gastroesophageal reflux symptoms.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 19%
Other 4 13%
Student > Master 4 13%
Professor 3 10%
Student > Ph. D. Student 3 10%
Other 7 23%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 10 32%
Agricultural and Biological Sciences 5 16%
Pharmacology, Toxicology and Pharmaceutical Science 4 13%
Biochemistry, Genetics and Molecular Biology 3 10%
Veterinary Science and Veterinary Medicine 1 3%
Other 3 10%
Unknown 5 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2020.
All research outputs
#1,325,596
of 21,415,800 outputs
Outputs from Clinical and Experimental Gastroenterology
#19
of 293 outputs
Outputs of similar age
#7,756
of 144,135 outputs
Outputs of similar age from Clinical and Experimental Gastroenterology
#3
of 8 outputs
Altmetric has tracked 21,415,800 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 293 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,135 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.