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The small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes

Overview of attention for article published in Biologics: Targets & Therapy, April 2012
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Title
The small leucine-rich proteoglycan, <em>biglycan</em>, is highly expressed in adipose tissue of <em>Psammomys obesus</em> and is associated with obesity and type 2 diabetes
Published in
Biologics: Targets & Therapy, April 2012
DOI 10.2147/btt.s27925
Pubmed ID
Authors

Kristy Bolton, Segal, Walder, Segal, Walder

Abstract

We have previously demonstrated that the small leucine-rich proteoglycan decorin may play a role in adipose tissue homeostasis and the pathophysiology of obesity. Biglycan is highly similar in structure to decorin, therefore we hypothesized it would have a similar expression profile and role to decorin in adipose tissue. Real time polymerase chain reaction was used to measure biglycan mRNA levels in adipose tissue from normal glucose tolerant and impaired glucose tolerant and type 2 diabetic (T2D) Psammomys obesus. Biglycan mRNA was found to be highly expressed in adipose tissue, and gene expression was significantly higher in visceral compared to subcutaneous adipose tissue, with elevated levels in obese, T2D compared to lean normal glucose tolerant P. obesus (P < 0.04). Biglycan mRNA was predominantly expressed by stromal/vascular cells of fractionated adipose tissue (P = 0.023). Biglycan expression in adipose tissue, particularly in the obese state, was markedly upregulated. Collectively, our data suggest that the small leucine-rich proteoglycan family proteins biglycan and decorin may play a role in the development of obesity and T2D, possibly by facilitating expansion of adipose tissue mass.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 36%
Student > Doctoral Student 2 18%
Student > Ph. D. Student 2 18%
Student > Bachelor 1 9%
Researcher 1 9%
Other 0 0%
Unknown 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 27%
Medicine and Dentistry 2 18%
Biochemistry, Genetics and Molecular Biology 1 9%
Nursing and Health Professions 1 9%
Chemistry 1 9%
Other 0 0%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2012.
All research outputs
#3,550,741
of 4,507,211 outputs
Outputs from Biologics: Targets & Therapy
#88
of 114 outputs
Outputs of similar age
#59,778
of 75,177 outputs
Outputs of similar age from Biologics: Targets & Therapy
#9
of 12 outputs
Altmetric has tracked 4,507,211 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 114 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.