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Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

Overview of attention for article published in Drug Design, Development and Therapy, June 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

twitter
4 tweeters
facebook
1 Facebook page

Citations

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14 Dimensions

Readers on

mendeley
29 Mendeley
Title
Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers
Published in
Drug Design, Development and Therapy, June 2016
DOI 10.2147/dddt.s103993
Pubmed ID
Authors

Yusuf Abba, Shaymaa Fadhel Abbas Albaayit, Rasedee Abdullah, Noorlidah Abdullah

Abstract

Clausena excavata is a natural herb with both antioxidant and anti-inflammatory properties. It has been used for decades in folkloric practice for the amelioration of various ailments. In this study, the gastroprotective activity of methanolic extract of C. excavata leaves (MECE) was determined in the Sprague Dawley rat ethanol-induced gastric ulcer model. Rats were pretreated with a single dose of vehicle (5% Tween 20), 20 mg/mL omeprazole, 400 and 200 mg/mL of MECE dissolved in 5% Tween 20. Ulcer was induced with 5 mL/kg of ethanol and stomach tissue was obtained after 1 hour. Histological examination was done on hematoxylin and eosin, periodic acid-Schiff, and immunochemically stained gastric mucosal tissues. Prostaglandin E2, superoxide dismutase, catalase, glutathione peroxidase, and lipid peroxidation levels of the gastric tissue homogenates were also determined. Significantly (P<0.05) smaller ulcer areas, less intense edema, and fewer leukocytes' infiltration were observed in MECE- and omeprazole-treated than in untreated gastric mucosa with ulcer. The gastric pH, mucus production, superoxide dismutase, catalase, and glutathione peroxidase contents increased, while the lipid peroxidation content decreased as a result of MECE treatment. Bcl-2-associated X protein was underexpressed, while heat shock protein 70 and transforming growth factor-beta protein were overexpressed in the ulcerated gastric mucosa tissues treated with omeprazole and MECE. Similarly, there was a reduction in the levels of tumor necrotic factor-alpha and interleukin-6, while the level of interleukin-10 was increased. This study showed that the gastroprotective effect of MECE is achieved through inhibition of gastric juice secretion and ulcer lesion development, stimulation of mucus secretion, elevation of gastric pH, reduction of reactive oxygen species production, inhibition of apoptosis in the gastric mucosa, and modulation of inflammatory cytokines.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 14%
Student > Master 4 14%
Student > Ph. D. Student 4 14%
Researcher 3 10%
Student > Postgraduate 2 7%
Other 7 24%
Unknown 5 17%
Readers by discipline Count As %
Medicine and Dentistry 5 17%
Biochemistry, Genetics and Molecular Biology 5 17%
Pharmacology, Toxicology and Pharmaceutical Science 5 17%
Agricultural and Biological Sciences 2 7%
Veterinary Science and Veterinary Medicine 1 3%
Other 3 10%
Unknown 8 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2016.
All research outputs
#3,402,644
of 7,992,937 outputs
Outputs from Drug Design, Development and Therapy
#222
of 1,021 outputs
Outputs of similar age
#98,437
of 246,060 outputs
Outputs of similar age from Drug Design, Development and Therapy
#13
of 60 outputs
Altmetric has tracked 7,992,937 research outputs across all sources so far. This one has received more attention than most of these and is in the 55th percentile.
So far Altmetric has tracked 1,021 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,060 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.