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Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers

Overview of attention for article published in Drug Design, Development and Therapy, June 2016
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

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4 tweeters
facebook
1 Facebook page

Citations

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27 Dimensions

Readers on

mendeley
38 Mendeley
Title
Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers
Published in
Drug Design, Development and Therapy, June 2016
DOI 10.2147/dddt.s103993
Pubmed ID
Authors

Yusuf Abba, Shaymaa Fadhel Abbas Albaayit, Rasedee Abdullah, Noorlidah Abdullah

Abstract

Clausena excavata is a natural herb with both antioxidant and anti-inflammatory properties. It has been used for decades in folkloric practice for the amelioration of various ailments. In this study, the gastroprotective activity of methanolic extract of C. excavata leaves (MECE) was determined in the Sprague Dawley rat ethanol-induced gastric ulcer model. Rats were pretreated with a single dose of vehicle (5% Tween 20), 20 mg/mL omeprazole, 400 and 200 mg/mL of MECE dissolved in 5% Tween 20. Ulcer was induced with 5 mL/kg of ethanol and stomach tissue was obtained after 1 hour. Histological examination was done on hematoxylin and eosin, periodic acid-Schiff, and immunochemically stained gastric mucosal tissues. Prostaglandin E2, superoxide dismutase, catalase, glutathione peroxidase, and lipid peroxidation levels of the gastric tissue homogenates were also determined. Significantly (P<0.05) smaller ulcer areas, less intense edema, and fewer leukocytes' infiltration were observed in MECE- and omeprazole-treated than in untreated gastric mucosa with ulcer. The gastric pH, mucus production, superoxide dismutase, catalase, and glutathione peroxidase contents increased, while the lipid peroxidation content decreased as a result of MECE treatment. Bcl-2-associated X protein was underexpressed, while heat shock protein 70 and transforming growth factor-beta protein were overexpressed in the ulcerated gastric mucosa tissues treated with omeprazole and MECE. Similarly, there was a reduction in the levels of tumor necrotic factor-alpha and interleukin-6, while the level of interleukin-10 was increased. This study showed that the gastroprotective effect of MECE is achieved through inhibition of gastric juice secretion and ulcer lesion development, stimulation of mucus secretion, elevation of gastric pH, reduction of reactive oxygen species production, inhibition of apoptosis in the gastric mucosa, and modulation of inflammatory cytokines.

Twitter Demographics

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 16%
Researcher 4 11%
Student > Ph. D. Student 4 11%
Student > Bachelor 4 11%
Student > Doctoral Student 2 5%
Other 9 24%
Unknown 9 24%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 18%
Medicine and Dentistry 6 16%
Biochemistry, Genetics and Molecular Biology 4 11%
Agricultural and Biological Sciences 3 8%
Chemistry 2 5%
Other 4 11%
Unknown 12 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2016.
All research outputs
#13,473,953
of 22,877,793 outputs
Outputs from Drug Design, Development and Therapy
#685
of 2,087 outputs
Outputs of similar age
#176,339
of 339,121 outputs
Outputs of similar age from Drug Design, Development and Therapy
#20
of 62 outputs
Altmetric has tracked 22,877,793 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,087 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,121 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.