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Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies

Overview of attention for article published in Drug Design, Development and Therapy, July 2012
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1 tweeter
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1 Facebook page

Citations

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49 Dimensions

Readers on

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105 Mendeley
Title
Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies
Published in
Drug Design, Development and Therapy, July 2012
DOI 10.2147/dddt.s25757
Pubmed ID
Authors

Jon Jin Kim, Keir, Marks

Abstract

Hemolytic uremic syndrome is the leading cause of acute kidney injury in childhood. Ninety percent of cases are secondary to gastrointestinal infection with shigatoxin-producing bacteria. In this review, we discuss the molecular mechanisms of shigatoxin leading to hemolytic uremic syndrome and the emerging role of the complement system and vascular endothelial growth factor in its pathogenesis. We also review the evidence for treatment options to date, in particular antibiotics, plasma exchange, and immunoadsorption, and link this to the molecular pathology. Finally, we discuss future avenues of treatment, including shigatoxin-binding agents and complement inhibitors, such as eculizumab.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 <1%
Germany 1 <1%
Unknown 101 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 17%
Student > Master 17 16%
Researcher 14 13%
Student > Ph. D. Student 10 10%
Other 9 9%
Other 24 23%
Unknown 13 12%
Readers by discipline Count As %
Medicine and Dentistry 48 46%
Agricultural and Biological Sciences 24 23%
Biochemistry, Genetics and Molecular Biology 7 7%
Immunology and Microbiology 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 4 4%
Unknown 14 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2013.
All research outputs
#3,556,170
of 5,037,615 outputs
Outputs from Drug Design, Development and Therapy
#404
of 744 outputs
Outputs of similar age
#51,973
of 78,751 outputs
Outputs of similar age from Drug Design, Development and Therapy
#8
of 11 outputs
Altmetric has tracked 5,037,615 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 744 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,751 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.