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Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain

Overview of attention for article published in Journal of Pain Research, August 2012
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Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

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24 Dimensions

Readers on

mendeley
80 Mendeley
Title
Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain
Published in
Journal of Pain Research, August 2012
DOI 10.2147/jpr.s33112
Pubmed ID
Authors

Joseph Pergolizzi, van de Laar, Langford, Mellinghoff, Morón Merchante, Srinivas Nalamachu, Joanne O'Brien, Perrot, Robert B. Raffa, Joseph V Pergolizzi, Jr, Mart van de Laar, Richard Langford, Hans-Ulrich Mellinghoff, Ignacio Morón Merchante, Joanne O’Brien, Serge Perrot, Robert B Raffa, Joseph V Pergolizzi Jr

Abstract

Pain is the most common reason patients seek medical attention and pain relief has been put forward as an ethical obligation of clinicians and a fundamental human right. However, pain management is challenging because the pathophysiology of pain is complex and not completely understood. Widely used analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol (acetaminophen) have been associated with adverse events. Adverse event rates are of concern, especially in long-term treatment or at high doses. Paracetamol and NSAIDs are available by prescription, over the counter, and in combination preparations. Patients may be unaware of the risk associated with high dosages or long-term use of paracetamol and NSAIDs. Clinicians should encourage patients to disclose all medications they take in a "do ask, do tell" approach that includes patient education about the risks and benefits of common pain relievers. The ideal pain reliever would have few risks and enhanced analgesic efficacy. Fixed-dose combination analgesics with two or more agents may offer additive or synergistic benefits to treat the multiple mechanisms of pain. Therefore, pain may be effectively treated while toxicity is reduced due to lower doses. One recent fixed-dose combination analgesic product combines tramadol, a centrally acting weak opioid analgesic, with low-dose paracetamol. Evidence-based guidelines recognize the potential value of combination analgesics in specific situations. The current guideline-based paradigm for pain treatment recommends NSAIDs for ongoing use with analgesics such as opioids to manage flares. However, the treatment model should evolve how to use low-dose combination products to manage pain with occasional use of NSAIDs for flares to avoid long-term and high-dose treatment with these analgesics. A next step in pain management guidelines should be targeted therapy when possible, or low-dose combination therapy or both, to achieve maximal efficacy with minimal toxicity.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 1%
Japan 1 1%
Korea, Republic of 1 1%
Unknown 77 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 18%
Student > Master 12 15%
Student > Postgraduate 8 10%
Student > Ph. D. Student 7 9%
Student > Doctoral Student 6 8%
Other 22 28%
Unknown 11 14%
Readers by discipline Count As %
Medicine and Dentistry 41 51%
Nursing and Health Professions 9 11%
Pharmacology, Toxicology and Pharmaceutical Science 7 9%
Neuroscience 1 1%
Agricultural and Biological Sciences 1 1%
Other 9 11%
Unknown 12 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2016.
All research outputs
#10,245,204
of 16,629,244 outputs
Outputs from Journal of Pain Research
#757
of 1,238 outputs
Outputs of similar age
#75,620
of 134,936 outputs
Outputs of similar age from Journal of Pain Research
#13
of 18 outputs
Altmetric has tracked 16,629,244 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,238 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 134,936 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.