RT @renesugar: Targeting Polyamine Metabolism for Control of Human Viral Diseases #MECFS #LongCovid https://t.co/pD0QzP1hR9

https://t.co/pD0QzP1hR9 "In this way, drugs suppressing polyamines could be an approach to an - HCMV infection."

https://t.co/pD0QzP1hR9 "The antiviral effect of polyamine depletion was rescued with exogenous polyamines addition." "The finding implied that polyamines were essential for viral replication."

https://t.co/pD0QzP1hR9 "The intracellular polyamine (spermidine and spermine) levels reduced by DFMO in both CMV-infected cells." "And they reported that polyamine-depletion with DFMO supplement reduced infectious HCMV replication by 6-log and 4-log uni

https://t.co/pD0QzP1hR9 "A study prepared human foreskin fibroblast (HFF) cells for the virus infected model, and another one used human diploid fibroblasts (MRC5) cells to infect with HCMV."

https://t.co/pD0QzP1hR9 "The infection suppressed cellular immunity in the body by decreasing the activity of killer T cells and NK cells."

https://t.co/pD0QzP1hR9 "Although the majority of patients with HCMV infection are asymptomatic, about 20% of them developed neurological deficits." "The HCMV infection in immunocompromised patients have more severe outcomes."

https://t.co/pD0QzP1hR9 "The SAT1 activity was decreased in EBV-infected cells, which increased the levels of polyamines and the occurrence of BL." "On the contrary, it could enhance infection of EBV by increasing the activity of SAT1 with DEMspm treatme

https://t.co/pD0QzP1hR9 "which bring to assumption that EBV is closely related to polyamines."

https://t.co/pD0QzP1hR9 "Polyamines play an important role in the development of tumors, for example, polyamines promoted the expression of key components of the SCFSkp2 complex (ubiquitin ligase complex) and led to degradation of p27Kip1 and finally prom

Targeting Polyamine Metabolism for Control of Human Viral Diseases #MECFS #LongCovid https://t.co/pD0QzP1hR9

Targeting Polyamine Metabolism for Control of Human Viral Diseases. https://t.co/CQaDOX7Hxh

El papel de las #poliaminas es fundamental para la infectividad y replicación de los #virus. La investigación está centrada en buscar #fármacos para frenar #pandemias como la #COVID19 La #dieta y el #estilo de vida también afecta a su metabolismo. 👇 https