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Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer

Overview of attention for article published in International Journal of Nanomedicine, October 2012
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1 tweeter

Citations

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Readers on

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17 Mendeley
Title
Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
Published in
International Journal of Nanomedicine, October 2012
DOI 10.2147/ijn.s34886
Pubmed ID
Authors

Baorui Liu, Li, Xu, Dai, Zhu, Lu

Abstract

Paclitaxel (Ptx), one of the most widely used anticancer agents, has demonstrated extraordinary activities against a variety of solid tumors. However, the therapeutic response of Ptx is often associated with severe side effects caused by its nonspecific cytotoxic effects and special solvents (Cremophor EL(®)). The current study reports the stable controlled release of Ptx/tetrandrine (Tet)-coloaded nanoparticles by amphilic methoxy poly(ethylene glycol)-poly(caprolactone) block copolymers. There were three significant findings. Firstly, Tet could effectively stabilize Ptx-loaded nanoparticles with the coencapsulation of Tet and Ptx. The influence of different Ptx/Tet feeding ratios on the size and loading efficiency of the nanoparticles was also explored. Secondly, the encapsulation of Tet and Ptx into nanoparticles retains the synergistic anticancer efficiency of Tet and Ptx against mice hepatoma H22 cells. Thirdly, in the in vivo evaluation, intratumoral administration was adopted to increase the site-specific delivery. Ptx/Tet nanoparticles, when delivered intratumorally, exhibited significantly improved antitumor efficacy; moreover, they substantially increased the overall survival in an established H22-transplanted mice model. Further investigation into the anticancer mechanisms of this nanodelivery system is under active consideration as a part of this ongoing research. The results suggest that Ptx/Tet-coloaded nanoparticles could be a potential useful chemotherapeutic formulation for liver cancer therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 6%
United States 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 35%
Student > Ph. D. Student 4 24%
Researcher 3 18%
Student > Bachelor 1 6%
Other 1 6%
Other 0 0%
Unknown 2 12%
Readers by discipline Count As %
Medicine and Dentistry 4 24%
Agricultural and Biological Sciences 4 24%
Chemistry 3 18%
Biochemistry, Genetics and Molecular Biology 2 12%
Physics and Astronomy 1 6%
Other 1 6%
Unknown 2 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2012.
All research outputs
#3,543,559
of 4,507,072 outputs
Outputs from International Journal of Nanomedicine
#936
of 1,146 outputs
Outputs of similar age
#61,932
of 79,969 outputs
Outputs of similar age from International Journal of Nanomedicine
#21
of 29 outputs
Altmetric has tracked 4,507,072 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 1.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 79,969 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.