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Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery

Overview of attention for article published in International Journal of Nanomedicine, October 2012
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Mentioned by

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1 tweeter

Citations

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27 Dimensions

Readers on

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33 Mendeley
Title
Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
Published in
International Journal of Nanomedicine, October 2012
DOI 10.2147/ijn.s33649
Pubmed ID
Authors

Bin He, Liu, Lai, Li, Wang, Chang, Zhongwei Gu

Abstract

A new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. Cinnamic-acid-modified poly(ethylene glycol) chains were threaded in α-cyclodextrins to form polyrotaxanes. The polyrotaxanes self-assembled supramolecular nanoparticles. The morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. The release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells with a drug concentration of 10 μg/mL; the cell survival rate was 3.3% after a 72-hour incubation. In an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. The tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. The cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 24%
Student > Ph. D. Student 6 18%
Professor 4 12%
Researcher 3 9%
Other 3 9%
Other 7 21%
Unknown 2 6%
Readers by discipline Count As %
Chemistry 10 30%
Agricultural and Biological Sciences 4 12%
Biochemistry, Genetics and Molecular Biology 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Medicine and Dentistry 2 6%
Other 6 18%
Unknown 5 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2012.
All research outputs
#17,240,401
of 21,338,376 outputs
Outputs from International Journal of Nanomedicine
#2,704
of 3,562 outputs
Outputs of similar age
#116,154
of 152,962 outputs
Outputs of similar age from International Journal of Nanomedicine
#30
of 38 outputs
Altmetric has tracked 21,338,376 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,562 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,962 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.