@ThomasMDas Thank you Tommy! Very happy to hear the IV approach is working. Also want to give credit to others (@syoungmd, @Paxbach, others) using microdosing for years in other contexts. First described in 2016 as the Burnese method (https://t.co/v17sv6IW
RT @SUDsPharmD_APPE: Buprenorphine microdosing gradually introduces small amts of BUP alongside full agonist at mu opioid receptor; does no…
Buprenorphine microdosing gradually introduces small amts of BUP alongside full agonist at mu opioid receptor; does not require withdrawal to start BUP which may render this strategy more tolerable to stabilize on BUP! https://t.co/43kaPAhyvM
@jack_turban There's preliminary evidence that microdosed buprenorphine induction, given along with full agonist as "bridge", can be done, and results in far fewer/less severe withdrawal symptoms. https://t.co/j7MQvefQdN
@NanouTheNomad @DrSarahWakeman @DrKimSue This is the article that people tend to reference: https://t.co/ZTAVC7p27Z I don't have experience with microdosing tho!
@AnIcarus @DrKimSue @PHS_PrimaryCare @DocVan_Nostrand @KeithAhamad @tdbrothers @DrSarahWakeman @Dinahlew @adfoxMD Can apply to buprenorphine induction as well: https://t.co/cJXjF1oysL
@DrMelissaWeimer @psychadvoc8 @liebschutz @JonGiftosMD @DrKimSue @PHS_PrimaryCare @adfoxMD @DrSarahWakeman @drmbierer @Dinahlew @DrChinazo @markeisenberg16 @simkimmel @honoraenglander @jessgregg1 https://t.co/Wag83esODf Use of microdoses for induction of b
@liebschutz @DrKimSue @DrMelissaWeimer @JonGiftosMD @PHS_PrimaryCare @adfoxMD @DrSarahWakeman @drmbierer @Dinahlew @DrChinazo @markeisenberg16 @simkimmel @honoraenglander @jessgregg1 https://t.co/Wag83esODf Use of microdoses for induction of buprenorphine
@del_mc101 @DuckDuckGo https://t.co/Wag83esODf Furthermore, it was shown that a very small dose of 0.2 mg buprenorphine intravenous (iv) did not produce opioid withdrawal in methadone-maintained individuals.19 https://t.co/bxVbFL7FXf
? @del_mc101 I was really lucky as when I began suboxone deep dive research not available on Google @DuckDuckGo didn't have search filters yet. I accidentally deleted most of my bookmarks but this link still is available with a little digging.
@del_mc101 @ToxAndHound @lapizity @cmurphytoxdoc @drusyniak @toxiferoustales @toxicologist12 @mbspyres @DavidJuurlink @jonbcole2 @DrDianeC @jmmarraffa @trevthomps https://t.co/Wag83esODf "Overlapping induction of a full antagonist assumed naltrexone could
@JonGiftosMD @drrickbarnett @Gail_G_Scott @adfoxMD @DrScottHadland @CDCDirector @samhsagov @US_FDA @Surgeon_General https://t.co/Wag83esODf "Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the Bernese me
https://t.co/Wag83esODf Between 40% and 60% of buprenorphine-maintained persons concomitantly use full µ-receptor agonists.10–12 According to patients’ accounts and experimental studies, this use is not associated with opioid withdrawal but attenuated subj
#imia19 Canada using the Bernese method of microdosing to avoid the preciptated withdrawal commonly associated with high dose fentanyl dependence and traditional induction. https://t.co/a8FU3DJALv
@michaelbmarlin @RyanMarino Were y’all in on that thread it was fascinating? Well, anyway here are two case studies microdosing from full agonist without naloxone. For methadone it takes 5 days, but once you get to 12mg bupe can stop methadone no taper. ht
https://t.co/Wag83esODf Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the Bernese method @AlecMacGillis Why did @OIGatHHS @HHSGov @samhsagov @CDCgov block microdose buprenorphine or naltrexone to walk
RT @supermarioelia: @DavidJuurlink You guys using much of the Bernese method on inpatients? https://t.co/chJqOV2VgP
@DavidJuurlink You guys using much of the Bernese method on inpatients? https://t.co/chJqOV2VgP
Switching from iv fentanyl use to suboxone. #microdose #microdoses #microdosing #fentanyl #suboxone #buprenorphine
https://t.co/ZMmlWDnTQm "Dont give up as precipated wd chased me away from subs into finally shit happened that got me to where i am now. Please check out those suggestions and read about #microdosing #microdose #buprenorphine in link below. More info here
@GnomeAndFairy @Artivizm @threadreaderapp Would love a Bupe microdosing Tweetorial as well. Tho definitely not my area of expertise. We'd need @RupiBrarMD @hakique @KeithAhamad @DocVan_Nostrand & others to throw that together. But they did share great
@michaelbmarlin @DrKimSue @JonGiftosMD @evolutionarypsy @JoshuaNiforatos @BCCSU @bccfe @ccsmd @VCHhealthcare @DocVan_Nostrand Also check out the original (English language) "Bernese method" papers: https://t.co/nzxYaR73op & this presentation from Dr.
@TNREthx https://t.co/Wag83esODf If every patient was given an 8 day blister pack of microdose naltrexone, microdose buprenorphine, or a combo to overlap their last 3-8 days of opiate pain meds we wouldn't have an opiate epidemic right now. https://t.co
@andrewkolodny @TNREthx @TEDTalks @samhsagov 🤯 @TNREthx https://t.co/Wag83esODf Study geared toward off chain opiate addiction - but protocol works for pain med taper> "We assumed (microdose) naltrexone could be initiated analogous to overlapping (co
https://t.co/Wag83esODf "Moreover, because of its low dissociation constant, buprenorphine separates slowly from the receptor once it is bound.14 The slow association/dissociation kinetics allow for 72-hour dosing intervals in buprenorphine treatment.4,15
@Gizmodo https://t.co/Wag83esODf @EdCara4 blister packs of microdoses of buprenorphine should be available to anyone trapped on opiates, heroin, or fentanyl that can overlap their last week of agonist use for a next to withdrawal free landing. But that cu
RT @earth_to_jen: @headdock @CDCgov @CDCDirector @nytimes @washingtonpost @CNN @NBCNews @CBSNews "If you are using fentanyl right now or kn…
@headdock @CDCgov @CDCDirector @nytimes @washingtonpost @CNN @NBCNews @CBSNews @missourinetwork ? https://t.co/Wag83esODf @headdock opiates became mainstream with pill mills- now ILLICIT fentanyl is opiate du jour- yet nobody except @missourinetwork @PHS_
@headdock @CDCgov @CDCDirector @nytimes @washingtonpost @CNN @NBCNews @CBSNews "If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market right now are lipid solvent. What..." @headdock @missourin
@ACLU_Mass @missourinetwork https://t.co/Wag83esODf ? @ACLU_Mass maybe research why mcg microdoses of buprenorphine and/or naltrexone are not available long before it gets to this point.
https://t.co/Wag83esODf @missourinetwork Swiss #bernese Method study also indicated microdose naltrexone could be used w overlap opiate use low/no withdrawal detox-$$$ treatment centers use detox Method w no overlap. Just like naloxone in suboxone naltrexo
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
https://t.co/Wag83eKpuN @missourinetwork more in depth review of microdose buprenorphine #bernese #MAT induction method overlapping full agonist use with low to no withdrawal
Fentanyl maybe needed catalyst to fast track protocol @DocVan_Nostrand @PHS_PrimaryCare are using including blister paks of microdose buprenorphine going mainstream @cmoraff @Beall1 @miriamboeri @ZachWritesStuff @drrickbarnett @CarePractice @Redimereinc @S
@CarePractice @cmoraff @Redimereinc @drrickbarnett @Beall1 @miriamboeri @ZachWritesStuff https://t.co/Wag83esODf In Swiss study microdose naltrexone was tailored to a hard nut trapped on heroin/buprenorphine hamster wheel. For her bupe made things worse-no
@CarePractice @cmoraff @Redimereinc @drrickbarnett @Beall1 @miriamboeri @ZachWritesStuff https://t.co/Wag83esODf For those stuck on the buprenorphine heroin cage wheel long enough (esp when docs dont quantitative drug test) microdose naltrexone is the get
Los analogos del #fentanilo que circulan en el mercado negro son liposolubles en grasa (si, al igual que el cannabis)... esto configura el uso de agonistas parciales como la bupre y/o metadona de forma distinta al uso convencional. Importante lo que dice @
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
RT @missourinetwork: If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market…
If you are using fentanyl right now or know someone who is please read this. The analogs that are on the black market right now are lipid solvent. What... https://t.co/gvpsmza0sM
@DocVan_Nostrand @tdbrothers @JonGiftosMD @ZachWritesStuff @AndrewMakeTweet @kimberlylsue @DrSarahWakeman @setmoreoff @audreymdmph @ACLakeMD @DrPoorman @adfoxMD https://t.co/Wag83esODf Months ago I sent the Switzerland bernese microdose induction or detox
@ACLakeMD in US strict guidelines only apply to buprenorphine naltrexone methadone for TREATMENT OF OUD- Detox, induction, taper, maintenance etc is NOT OUD TX. Microdosing of bupe or naltrexone is in the clear.
Micro dose rotation to Buprenorphine. Great newish tool for addiction and chronic pain. #addictionMD
@tdbrothers @JonGiftosMD @ZachWritesStuff @AndrewMakeTweet @kimberlylsue @DrSarahWakeman @setmoreoff @audreymdmph @ACLakeMD @DrPoorman @adfoxMD This is paper that everyone running with and trying to figure out how to make work best... https://t.co/bM59kYYw
@CarePractice @POTUS @FLOTUS @WhiteHouse @MickMulvaneyOMB @NIDAnews @NIHDirector @CDCDirector @SGottliebFDA @YaleMed @SHSanders45 @KellyannePolls @andrewkolodny @headdock @drrickbarnett @StefanKertesz @LeoBeletsky "Use of microdoses of bupe (or naltrexone)
@03_jensen @DanLairdMD @PainNewsNetwork @CDCDirector @SGottliebFDA @US_FDA @NIHDirector @CDCgov @samhsagov @ASAMorg @HHSGov https://t.co/Wag83esODf "Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the B
@dreamr9876 @Redimereinc @CarePractice @cmoraff @SGottliebFDA @NIHDirector @CDCDirector @US_FDA https://t.co/Wag83esODf After tapering of bupe to 2 mg/patient started w small amounts of naltrexone scratched off from tab+⬆️ dose daily-no withdrawal symptoms
@CarePractice @Redimereinc @dreamr9876 @cmoraff @SGottliebFDA @NIHDirector @CDCDirector @US_FDA https://t.co/Wag83esODf This one is the graphs from the rockstars in Bern and Basel Switzerland . The Transdermal Bupe study (also Switerland) older yet stil
RT @earth_to_jen: @adfoxMD https://t.co/Wag83esODf Use of microdoses of bupe (or naltrexone) for minimal to withdrawal free FULL DETOX or M…
@adfoxMD https://t.co/Wag83esODf Use of microdoses of bupe (or naltrexone) for minimal to withdrawal free FULL DETOX or MAT INDUCTION while overlapping full opioid agonist use: Bernese method from Bern Switzerland >
@CarePractice @tino_fuentes123 @Redimereinc @jonathan_giftos @Wanita1 @ZachWritesStuff @mattcurtisnyc @SkipSvioklaMD https://t.co/Wag83esODf "After taper bupe to 2 mg/d pt started small amounts of naltrexone scratched off from a tablet+⬆️ dose daily-didn
@drrickbarnett @true_morgan @vtdigger @vtdigger https://t.co/Wag83esODf Use of microdoses of naltrexone or bupe overlapping full/partial opioid agonist use (heroin oxys methadone suboxone etc) for next to withdrawal free MAT induction or full detox: Bern
@SharpePotter would love to see study of microdoses of bupe OR naltrexone handed out to suds active in their addiction who report to SIFs or needle exchange programs. Also study on microdose bupe or naltrexone overlapping expecting moms opiate use to gauge
@SharpePotter @TXHealthJournal @UTHealthSA @DavidLakey_MD @OperationNLX @HillPharmD @UTHealthBiomed https://t.co/Wag83esODf "Use of microdoses of bupe OR naltrexone for induction of MAT treatment with overlapping full or partial opioid agonist use: Bernes
@JWhelanRN @drrickbarnett @JeffBezos @amazon https://t.co/Wag83esODf Oh girl! Don't get me started on low and ultra low dose GENERIC naltrexone and the opioid epidemic
@scottluetgenau @LeoBeletsky https://t.co/Wag83esODf Use of microdoses of bupe OR naltrexone for induction of MAT treatment without prerequisite withdrawal requirement while overlapping full opioid agonist heroin methadone use or suboxone use : the Bernese
@MMcFarlandSM current drug death response policy is low bar drain circling like NARCAN & prerequisite OD or withdrawal pre MAT induction access. Ultra & low dose mcg 0.Xmg naltrexone & bupe should be as available as NARCAN at needle exchange pr
@DrugPolicyOrg https://t.co/Wag83esODf Use of microdoses of bupe OR naltrexone for next to withdrawal free MAT induction, MAT transfer, or full detox with overlapping full opioid agonist heroin methadone use or suboxone use: the Swiss Bernese method @eliza
https://t.co/Wag83esODf @AddictionDrW "Use of microdoses of bupe OR naltrexone for induction of MAT treatment (less withdrawal better retention) w overlapping full opioid agonist (street heroin methadone etc) or suboxone use: Swiss Bernese method"
https://t.co/Wag83esODf microdoses of bupe or naltrexone induction of MAT w overlapping full opioid agonist use: Bernese method Bupe or VIVITROL MAT induced by overlapping w street heroin use / OMT w high-dosed full µ-agonists @sciam @YesToSCS @alexhkral
@Manyatch @drrickbarnett https://t.co/Wag83esODf Use of microdoses of buprenorphine or naltrexone with overlapping full opioid agonist use to skip prerequisite withdrawal requirement for detox or MAT suboxone or VIVITROL induction #BerneseMethod via res
@drrickbarnett Yes. It's called Bernese Method based on research from Bern Switzerland: "Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the Bernese method" https://t.co/Wag83esODf
@RecoveryInsider @lizflock @lizflock https://t.co/Wag83esODf And that relatively "new" naltrexone (or microdoses of bupe) could be a game changer
@TimCarnell04 @dreamr9876 @JoeBiden @senorrinhatch @BillClinton @US_FDA Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the Bernese method https://t.co/Wag83esODf here Bern & Basel Switzerland study
@drrickbarnett microdoses for induction of bupe treatment w overlapping full opioid agonist use: Bernese method https://t.co/Wag83esODf NO WITHDRAWAL PREREQUISITES: bupe increased gradually w overlapping full agonist methadone dose>target dose reached
Use those diverted suboxone strips you buy from your heroin dealer wisely 😎 https://t.co/PVkBgqkzaT
https://t.co/Wag83esODf overlapping buprenorphine induction w Bernese method (ie, start w low dose of 0.2 mg bupe overlapping w heroin use, small daily dose increases>abrupt cessation of heroin use at sufficient dose) #harmreduction #opioidhysteria #
More research showing this could work. https://t.co/qCCg5c5ThF
https://t.co/Wag83esODf Overlapping induction of buprenorphine maintenance treatment with full µ-opioid receptor agonists heroin use: ✔feasible ✔may be associated with better tolerability and acceptability in some patients compared to the conventional
@mojo3638 @JanWiderman @drrickbarnett @SGottliebFDA @US_FDA https://t.co/Wag83esODf Use of microdoses of buprenorphine or naltrexone for induction to or detox off methadone heroin suboxone treatment (with overlapping full opioid agonist use): the Bernese