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Autophagy as a target for cancer therapy: new developments

Overview of attention for article published in Cancer Management and Research, October 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent

Citations

dimensions_citation
112 Dimensions

Readers on

mendeley
85 Mendeley
Title
Autophagy as a target for cancer therapy: new developments
Published in
Cancer Management and Research, October 2012
DOI 10.2147/cmar.s26133
Pubmed ID
Authors

Steffan Nawrocki, Carew, Kelly

Abstract

Autophagy is an evolutionarily conserved lysosomal degradation pathway that eliminates cytosolic proteins, macromolecules, organelles, and protein aggregates. Activation of autophagy may function as a tumor suppressor by degrading defective organelles and other cellular components. However, this pathway may also be exploited by cancer cells to generate nutrients and energy during periods of starvation, hypoxia, and stress induced by chemotherapy. Therefore, induction of autophagy has emerged as a drug resistance mechanism that promotes cancer cell survival via self-digestion. Numerous preclinical studies have demonstrated that inhibition of autophagy enhances the activity of a broad array of anticancer agents. Thus, targeting autophagy may be a global anticancer strategy that may improve the efficacy of many standard of care agents. These results have led to multiple clinical trials to evaluate autophagy inhibition in combination with conventional chemotherapy. In this review, we summarize the anticancer agents that have been reported to modulate autophagy and discuss new developments in autophagy inhibition as an anticancer strategy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 1%
Unknown 84 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 21%
Student > Master 16 19%
Researcher 11 13%
Student > Bachelor 10 12%
Student > Doctoral Student 7 8%
Other 15 18%
Unknown 8 9%
Readers by discipline Count As %
Medicine and Dentistry 23 27%
Agricultural and Biological Sciences 23 27%
Biochemistry, Genetics and Molecular Biology 13 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Immunology and Microbiology 2 2%
Other 7 8%
Unknown 13 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2018.
All research outputs
#4,664,542
of 17,351,915 outputs
Outputs from Cancer Management and Research
#119
of 1,331 outputs
Outputs of similar age
#35,389
of 143,145 outputs
Outputs of similar age from Cancer Management and Research
#4
of 12 outputs
Altmetric has tracked 17,351,915 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,331 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,145 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.