| Title |
Depression and pain: testing of serial multiple mediators
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, July 2016
|
| DOI | 10.2147/ndt.s110383 |
| Pubmed ID | |
| Authors |
Tinakon Wongpakaran, Nahathai Wongpakaran, Sitthinant Tanchakvaranont, Putipong Bookkamana, Manee Pinyopornpanish, Kamonporn Wannarit, Sirina Satthapisit, Daochompu Nakawiro, Thanita Hiranyatheb, Kulvadee Thongpibul |
| Abstract |
Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders. An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed. Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator. Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in clinical application. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 100 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 22% |
| Student > Master | 15 | 15% |
| Researcher | 14 | 14% |
| Student > Doctoral Student | 11 | 11% |
| Student > Bachelor | 7 | 7% |
| Other | 12 | 12% |
| Unknown | 19 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 32 | 32% |
| Medicine and Dentistry | 14 | 14% |
| Social Sciences | 12 | 12% |
| Business, Management and Accounting | 7 | 7% |
| Nursing and Health Professions | 4 | 4% |
| Other | 7 | 7% |
| Unknown | 24 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2018.
All research outputs
#14,276,973
of 25,373,627 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,253
of 3,132 outputs
Outputs of similar age
#186,704
of 367,255 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#51
of 107 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.