| Title |
Controlled-release approaches towards the chemotherapy of tuberculosis
|
|---|---|
| Published in |
International Journal of Nanomedicine, October 2012
|
| DOI | 10.2147/ijn.s34996 |
| Pubmed ID | |
| Authors |
Bullo Saifullah, Mohd Zobir B Hussein, Samer Hasan Hussein Al Ali |
| Abstract |
Tuberculosis (TB), caused by the bacteria Mycobacterium tuberculosis, is notorious for its lethality to humans. Despite technological advances, the tubercle bacillus continues to threaten humans. According to the World Health Organization's 2011 global report on TB, 8.8 million cases of TB were reported in 2010, with a loss of 1.7 million human lives. As drug-susceptible TB requires long-term treatment of between 6 and 9 months, patient noncompliance remains the most important reason for treatment failure. For multidrug-resistant TB, patients must take second-line anti-TB drugs for 18-24 months and many adverse effects are associated with these drugs. Drug-delivery systems (DDSs) seem to be the most promising option for advancement in the treatment of TB. DDSs reduce the adverse effects of drugs and their dosing frequency as well as shorten the treatment period, and hence improve patient compliance. Further advantages of these systems are that they target the disease area, release the drugs in a sustained manner, and are biocompatible. In addition, targeted delivery systems may be useful in dealing with extensively drug-resistant TB because many side effects are associated with the drugs used to cure the disease. In this paper, we discuss the DDSs developed for the targeted and slow delivery of anti-TB drugs and their possible advantages and disadvantages. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 1% |
| Unknown | 94 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Student > Master | 17 | 18% |
| Researcher | 15 | 16% |
| Student > Bachelor | 11 | 12% |
| Student > Doctoral Student | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 20 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 21% |
| Chemistry | 9 | 9% |
| Agricultural and Biological Sciences | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Materials Science | 5 | 5% |
| Other | 22 | 23% |
| Unknown | 24 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2013.
All research outputs
#20,110,957
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#2,965
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Outputs of similar age
#143,935
of 191,340 outputs
Outputs of similar age from International Journal of Nanomedicine
#47
of 53 outputs
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