| Title |
Alteration of spontaneous brain activity in COPD patients
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, July 2016
|
| DOI | 10.2147/copd.s110089 |
| Pubmed ID | |
| Authors |
Jiaxing Zhang, Ji Chen, Qian Yu, Cunxiu Fan, Ran Zhang, Jianzhong Lin, Tianhe Yang, Ming Fan |
| Abstract |
Airflow limitation in chronic obstructive pulmonary disease (COPD) results in a decrease in oxygen transport to the brain. The aim of the present study was to explore the alteration of spontaneous brain activity induced by hypoxia in patients with COPD. Twenty-five stable patients with COPD and 25 matching healthy volunteers were investigated. Amplitude of low-frequency fluctuation (ALFF) of blood oxygenation level-dependent signal at resting state in the brain was analyzed using functional magnetic resonance imaging. Whole-brain analysis using functional magnetic resonance imaging revealed significant decreases in ALFF in the bilateral posterior cingulate gyri and right lingual gyrus and an increase in ALFF in the left postcentral gyrus of patients with COPD. After controlling for SaO2, patients with COPD only showed an increase in ALFF in the left postcentral gyrus. Region of interest analysis showed a decrease in ALFF in the left precentral gyrus and an increase in ALFF in the left caudate nucleus of patients with COPD. In all subjects, ALFF in the bilateral posterior cingulate gyri and right lingual gyrus showed positive correlations with visual reproduction. We demonstrated abnormal spontaneous brain activity of patients with COPD, which may have a pathophysiologic meaning. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 21% |
| Student > Ph. D. Student | 4 | 14% |
| Other | 3 | 11% |
| Student > Doctoral Student | 3 | 11% |
| Researcher | 2 | 7% |
| Other | 1 | 4% |
| Unknown | 9 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 5 | 18% |
| Medicine and Dentistry | 5 | 18% |
| Physics and Astronomy | 2 | 7% |
| Neuroscience | 2 | 7% |
| Sports and Recreations | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 10 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2016.
All research outputs
#16,862,842
of 25,576,275 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,616
of 2,585 outputs
Outputs of similar age
#228,316
of 367,816 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#68
of 96 outputs
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