Title |
The use of capecitabine in daily practice: a study on adherence and patients' experiences
|
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Published in |
Patient preference and adherence, October 2012
|
DOI | 10.2147/ppa.s36757 |
Pubmed ID | |
Authors |
Lonneke Timmers, Eleonora L Swart, Christel CLM Boons, Dirk Mangnus, Peter M van de Ven, Godefridus J Peters, Epie Boven, Jacqueline G Hugtenburg |
Abstract |
Adherence to pharmacological therapy is a complex and multifactorial issue that can substantially alter the outcome of treatment. Especially when using long-term medication, cancer patients have adherence rates similar to those of patients with other diseases. The consequences of poor adherence are poor health outcomes and increased health care costs. Only few studies have focused on the use of oral anticancer agents in daily practice. Information about the reasons for nonadherence is essential for the development of interventions that may improve adherence. This report presents the CAPER-capecitabine protocol, which is designed to study the adherence to capecitabine and the influence of patient attitudes towards medication and self-reported side effects. Furthermore, the relationships between patient characteristics, disease characteristics, side effects, quality of life, patient beliefs and attitudes towards disease and medication, dose adjustments, reasons for discontinuation, and plasma concentration of three of the main metabolites, including the active compound 5-fluorouracil, will be explored. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 5% |
Unknown | 63 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 15% |
Student > Master | 10 | 15% |
Researcher | 6 | 9% |
Other | 4 | 6% |
Professor > Associate Professor | 4 | 6% |
Other | 12 | 18% |
Unknown | 20 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 12% |
Nursing and Health Professions | 5 | 8% |
Agricultural and Biological Sciences | 5 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 9 | 14% |
Unknown | 22 | 33% |