| Title |
Update and new approaches in the treatment of Castleman disease
|
|---|---|
| Published in |
Journal of Blood Medicine, August 2016
|
| DOI | 10.2147/jbm.s60514 |
| Pubmed ID | |
| Authors |
Kah-Lok Chan, Stephen Lade, H Miles Prince, Simon J Harrison |
| Abstract |
First described 60 years ago, Castleman disease comprises a rare and heterogeneous cluster of disorders, characterized by lymphadenopathy with unique histological features and associated with cytokine-driven constitutional symptoms and biochemical disturbances. Although unicentric Castleman disease is curable with complete surgical excision, its multicentric counterpart is a considerable therapeutic challenge. The recent development of biological agents, particularly monoclonal antibodies to interleukin-6 and its receptor, allow for more targeted disease-specific intervention that promises improved response rates and more durable disease control; however, further work is required to fill knowledge gaps in terms of underlying pathophysiology and to facilitate alternative treatment options for refractory cases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 17 | 22% |
| Other | 12 | 16% |
| Researcher | 11 | 14% |
| Student > Doctoral Student | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 15 | 19% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 56 | 73% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Neuroscience | 2 | 3% |
| Linguistics | 1 | 1% |
| Agricultural and Biological Sciences | 1 | 1% |
| Other | 5 | 6% |
| Unknown | 10 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2016.
All research outputs
#15,380,722
of 22,881,964 outputs
Outputs from Journal of Blood Medicine
#148
of 289 outputs
Outputs of similar age
#237,463
of 366,376 outputs
Outputs of similar age from Journal of Blood Medicine
#5
of 8 outputs
Altmetric has tracked 22,881,964 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 289 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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