Title |
Optimal management of pernicious anemia
|
---|---|
Published in |
Journal of Blood Medicine, September 2012
|
DOI | 10.2147/jbm.s25620 |
Pubmed ID | |
Authors |
Emmanuel Andres, Khalid Serraj |
Abstract |
Pernicious anemia (also known as Biermer's disease) is an autoimmune atrophic gastritis, predominantly of the fundus, and is responsible for a deficiency in vitamin B12 (cobalamin) due to its malabsorption. Its prevalence is 0.1% in the general population and 1.9% in subjects over the age of 60 years. Pernicious anemia represents 20%-50% of the causes of vitamin B12 deficiency in adults. Given its polymorphism and broad spectrum of clinical manifestations, pernicious anemia is a great pretender. Its diagnosis must therefore be evoked and considered in the presence of neurological and hematological manifestations of undetermined origin. Biologically, it is characterized by the presence of anti-intrinsic factor antibodies. Treatment is based on the administration of parenteral vitamin B12, although other routes of administration (eg, oral) are currently under study. In the present update, these various aspects are discussed with special emphasis on data of interest to the clinician. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 50% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | <1% |
Morocco | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 194 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 54 | 27% |
Student > Master | 25 | 13% |
Student > Postgraduate | 17 | 9% |
Researcher | 12 | 6% |
Other | 10 | 5% |
Other | 25 | 13% |
Unknown | 54 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 73 | 37% |
Agricultural and Biological Sciences | 18 | 9% |
Biochemistry, Genetics and Molecular Biology | 14 | 7% |
Nursing and Health Professions | 14 | 7% |
Immunology and Microbiology | 3 | 2% |
Other | 18 | 9% |
Unknown | 57 | 29% |