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Role of CD44 as a marker of cancer stem cells in head and neck cancer

Overview of attention for article published in Biologics: Targets & Therapy, November 2012
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Title
Role of CD44 as a marker of cancer stem cells in head and neck cancer
Published in
Biologics: Targets & Therapy, November 2012
DOI 10.2147/btt.s37906
Pubmed ID
Authors

Serena Trapasso, Eugenia Allegra

Abstract

In recent years, many studies have shown that some types of tumors are characterized by the presence of cells with stem-like characteristics, called cancer stem cells (CSCs). These are considered cells that initiate the tumor and are probably responsible for tumor recurrence. CSCs have the capacity for self-renewal, the potential to give rise to one or more cell types within the tumor, and the ability to drive, in a continuous manner, the proliferation of malignant cells. The failure of current cancer therapies can be attributed to the relative ineffectiveness of drugs against CSCs, which remain viable while retaining their full ability to reproduce the tumor. The development of new strategies is currently hampered by the lack of reliable markers to identify CSCs. One promising surface marker of CSCs in head and neck cancer is the CD44 molecule, which has been shown in preliminary studies to have high specificity, although there are discrepant data because its prognostic value may depend on the specific tumor location. More rigorous studies are needed to investigate the usefulness of CD44 expression in head and neck tumors for possible clinical applicability.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 28%
Researcher 8 15%
Other 6 11%
Student > Bachelor 5 9%
Student > Doctoral Student 5 9%
Other 9 17%
Unknown 6 11%
Readers by discipline Count As %
Medicine and Dentistry 20 37%
Agricultural and Biological Sciences 11 20%
Biochemistry, Genetics and Molecular Biology 10 19%
Chemistry 2 4%
Social Sciences 1 2%
Other 3 6%
Unknown 7 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2012.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Biologics: Targets & Therapy
#224
of 284 outputs
Outputs of similar age
#158,246
of 202,252 outputs
Outputs of similar age from Biologics: Targets & Therapy
#4
of 6 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 284 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,252 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.