| Title |
Application of magnetically induced hyperthermia in the model protozoan Crithidia fasciculata as a potential therapy against parasitic infections
|
|---|---|
| Published in |
International Journal of Nanomedicine, October 2012
|
| DOI | 10.2147/ijn.s35510 |
| Pubmed ID | |
| Authors |
V Grazú, AM Silber, M Moros, L Asín, TE Torres, C Marquina, Ibarra, GF Goya |
| Abstract |
Magnetic hyperthermia is currently a clinical therapy approved in the European Union for treatment of tumor cells, and uses magnetic nanoparticles (MNPs) under time-varying magnetic fields (TVMFs). The same basic principle seems promising against trypanosomatids causing Chagas disease and sleeping sickness, given that the therapeutic drugs available have severe side effects and that there are drug-resistant strains. However, no applications of this strategy against protozoan-induced diseases have been reported so far. In the present study, Crithidia fasciculata, a widely used model for therapeutic strategies against pathogenic trypanosomatids, was targeted with Fe(3)O(4) MNPs in order to provoke cell death remotely using TVMFs. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 30% |
| Researcher | 10 | 14% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 5 | 7% |
| Professor | 4 | 6% |
| Other | 13 | 18% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 11 | 15% |
| Chemistry | 10 | 14% |
| Materials Science | 10 | 14% |
| Medicine and Dentistry | 7 | 10% |
| Other | 8 | 11% |
| Unknown | 12 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2012.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#2,469
of 4,123 outputs
Outputs of similar age
#125,659
of 190,995 outputs
Outputs of similar age from International Journal of Nanomedicine
#45
of 57 outputs
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