Title |
Diagnosis and management of catamenial seizures: a review
|
---|---|
Published in |
International Journal of Women's Health, September 2012
|
DOI | 10.2147/ijwh.s28872 |
Pubmed ID | |
Authors |
Alberto Verrotti, Claudia D’Egidio, Sergio Agostinelli, Carla Verrotti, Piero Pavone |
Abstract |
Catamenial epilepsy is defined as a pattern of seizures that changes in severity during particular phases of the menstrual cycle, wherein estrogens are proconvulsant, increasing the neuronal excitability; and progesterone is anticonvulsant, enhancing GABA-mediated inhibition. Thus, changes in serum estradiol/progesterone ratio throughout a normal reproductive cycle bring about an increased or decreased risk of seizure occurrence. To date, there are no specific drug treatments for catamenial epilepsy however, non-hormonal and hormonal therapies have been proposed. The aim of this review is to report preclinical and clinical evidences about the relationship between female reproductive steroids and epileptic seizures, and to describe treatment approaches for catamenial epilepsy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 86 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 23% |
Student > Master | 9 | 10% |
Student > Ph. D. Student | 7 | 8% |
Student > Postgraduate | 6 | 7% |
Student > Doctoral Student | 5 | 6% |
Other | 19 | 22% |
Unknown | 20 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 29% |
Neuroscience | 13 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Nursing and Health Professions | 4 | 5% |
Other | 10 | 12% |
Unknown | 22 | 26% |