| Title |
Reducing the iron burden and improving survival in transfusion-dependent thalassemia patients: current perspectives
|
|---|---|
| Published in |
Journal of Blood Medicine, August 2016
|
| DOI | 10.2147/jbm.s61540 |
| Pubmed ID | |
| Authors |
Karim Bayanzay, Lama Alzoebie |
| Abstract |
Hypertransfusion regimens for thalassemic patients revolutionized the management of severe thalassemia; transforming a disease which previously led to early infant death into a chronic condition. The devastating effect of the accrued iron from chronic blood transfusions necessitates a more finely tuned approach to limit the complications of the disease, as well as its treatment. A comprehensive approach including carefully tailored transfusion protocol, continuous monitoring and assessment of total body iron levels, and iron chelation are currently the mainstay in treating iron overload. There are also indications for ancillary treatments, such as splenectomy and fetal hemoglobin induction. The main cause of death in iron overload continues to be related to cardiac complications. However, since the widespread use of iron chelation started in the 1970s, there has been a general improvement in survival in these patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 57 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 6 | 10% |
| Student > Master | 5 | 9% |
| Student > Bachelor | 5 | 9% |
| Researcher | 3 | 5% |
| Professor > Associate Professor | 3 | 5% |
| Other | 13 | 22% |
| Unknown | 23 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 33% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Nursing and Health Professions | 3 | 5% |
| Agricultural and Biological Sciences | 2 | 3% |
| Unspecified | 2 | 3% |
| Other | 5 | 9% |
| Unknown | 23 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2016.
All research outputs
#20,337,210
of 22,882,389 outputs
Outputs from Journal of Blood Medicine
#242
of 289 outputs
Outputs of similar age
#321,207
of 366,370 outputs
Outputs of similar age from Journal of Blood Medicine
#6
of 8 outputs
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So far Altmetric has tracked 289 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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