| Title |
Effects of silver nanoparticles in combination with antibiotics on the resistant bacteria Acinetobacter baumannii
|
|---|---|
| Published in |
International Journal of Nanomedicine, August 2016
|
| DOI | 10.2147/ijn.s104166 |
| Pubmed ID | |
| Authors |
Guoqing Wan, Lingao Ruan, Yu Yin, Tian Yang, Mei Ge, Xiaodong Cheng |
| Abstract |
Acinetobacter baumannii resistance to carbapenem antibiotics is a serious clinical challenge. As a newly developed technology, silver nanoparticles (AgNPs) show some excellent characteristics compared to older treatments, and are a candidate for combating A. baumannii infection. However, its mechanism of action remains unclear. In this study, we combined AgNPs with antibiotics to treat carbapenem-resistant A. baumannii (aba1604). Our results showed that single AgNPs completely inhibited A. baumannii growth at 2.5 μg/mL. AgNP treatment also showed synergistic effects with the antibiotics polymixin B and rifampicin, and an additive effect with tigecyline. In vivo, we found that AgNPs-antibiotic combinations led to better survival ratios in A. baumannii-infected mouse peritonitis models than that by single drug treatment. Finally, we employed different antisense RNA-targeted Escherichia coli strains to elucidate the synergistic mechanism involved in bacterial responses to AgNPs and antibiotics. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Practitioners (doctors, other healthcare professionals) | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | <1% |
| Unknown | 153 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 12% |
| Student > Ph. D. Student | 18 | 12% |
| Researcher | 16 | 10% |
| Student > Bachelor | 11 | 7% |
| Student > Doctoral Student | 8 | 5% |
| Other | 34 | 22% |
| Unknown | 48 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 23 | 15% |
| Biochemistry, Genetics and Molecular Biology | 19 | 12% |
| Agricultural and Biological Sciences | 16 | 10% |
| Chemistry | 14 | 9% |
| Medicine and Dentistry | 8 | 5% |
| Other | 18 | 12% |
| Unknown | 56 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2016.
All research outputs
#8,186,312
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#996
of 4,123 outputs
Outputs of similar age
#131,432
of 381,036 outputs
Outputs of similar age from International Journal of Nanomedicine
#29
of 127 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 381,036 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.