| Title |
Improvement in social and cognitive functioning associated with paliperidone extended-release treatment in patients with schizophrenia: a 24-week, single arm, open-label study
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, August 2016
|
| DOI | 10.2147/ndt.s112542 |
| Pubmed ID | |
| Authors |
Chuan Shi, Shu Qiao Yao, Yi Feng Xu, Jian Guo Shi, Xiu Feng Xu, Cong Pei Zhang, Hua Jin, Xin Yu |
| Abstract |
This single-arm, open-label study aimed to explore the effects of extended-release paliperidone on social and cognitive function in patients with schizophrenia. Paliperidone extended-release (flexible dose ranging from 3 to 12 mg/day orally) was administered for 24 weeks in patients with schizophrenia. Patient function was assessed using the personal and social performance scale, measurement and treatment research to improve cognition in schizophrenia initiative-consensus cognitive battery, positive and negative syndrome scale, and clinical global impression-severity. Ninety patients were included in the full analysis set, while 72 patients were included in the per protocol set. The personal and social performance score was 54.3±14.3 at baseline, and significantly increased to 73.4±12.6 at week 24 (P<0.001). For the measurement and treatment research to improve cognition in schizophrenia initiative-consensus cognitive battery assessment, six of the nine individual subtests, six of the seven cognitive domains, and total cognitive scores improved significantly (P<0.05) between baseline and endpoint. positive and negative syndrome scale total scores and clinical global impression-severity scores decreased gradually (P<0.001) from week 4 to the conclusion of the study. Paliperidone extended-release treatment significantly improves social and neurocognitive function as well as symptoms in Chinese patients with schizophrenia. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 17% |
| Researcher | 4 | 14% |
| Professor > Associate Professor | 4 | 14% |
| Student > Ph. D. Student | 3 | 10% |
| Student > Master | 2 | 7% |
| Other | 4 | 14% |
| Unknown | 7 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 6 | 21% |
| Neuroscience | 3 | 10% |
| Nursing and Health Professions | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Social Sciences | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 11 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2016.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,192
of 3,132 outputs
Outputs of similar age
#284,463
of 381,036 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#95
of 102 outputs
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