| Title |
Skeletal muscle molecular alterations precede whole-muscle dysfunction in NYHA Class II heart failure patients
|
|---|---|
| Published in |
Clinical Interventions in Aging, November 2012
|
| DOI | 10.2147/cia.s37879 |
| Pubmed ID | |
| Authors |
Michael P Godard, Samantha A Whitman, Yao-Hua Song, Patrice Delafontaine |
| Abstract |
Heart failure (HF), a debilitating disease in a growing number of adults, exerts structural and neurohormonal changes in both cardiac and skeletal muscles. However, these alterations and their affected molecular pathways remain uncharacterized. Disease progression is known to transform skeletal muscle fiber composition by unknown mechanisms. In addition, perturbation of specific hormonal pathways, including those involving skeletal muscle insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-5 (IGFB-5) appears to occur, likely affecting muscle metabolism and regeneration. We hypothesized that changes in IGF-1 and IGFB-5 mRNA levels correlate with the transformation of single-skeletal muscle fiber myosin heavy chain isoforms early in disease progression, making these molecules valuable markers of skeletal muscle changes in heart failure. |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 5% |
| Portugal | 1 | 2% |
| Unknown | 39 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 7 | 17% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Master | 5 | 12% |
| Student > Bachelor | 4 | 10% |
| Researcher | 3 | 7% |
| Other | 10 | 24% |
| Unknown | 8 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 29% |
| Agricultural and Biological Sciences | 9 | 21% |
| Nursing and Health Professions | 4 | 10% |
| Sports and Recreations | 3 | 7% |
| Neuroscience | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 12 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2012.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Clinical Interventions in Aging
#1,779
of 1,968 outputs
Outputs of similar age
#181,460
of 202,252 outputs
Outputs of similar age from Clinical Interventions in Aging
#20
of 22 outputs
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