Title |
Clinical management of a challenging malignancy, osteoblastoma-like osteosarcoma: a report of four cases and a review of the literature
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Published in |
Therapeutics and Clinical Risk Management, August 2016
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DOI | 10.2147/tcrm.s102966 |
Pubmed ID | |
Authors |
Harzem Ozger, Bugra Alpan, Mehmet Salih Söylemez, Korhan Ozkan, Ahmet Salduz, Bilge Bilgic, Basak Kumbasar Sirin |
Abstract |
Osteoblastoma-like osteosarcoma, a rare form of osteosarcoma, is a malignant lesion associated with risks of both local recurrence and distant metastasis. The differential diagnosis of osteoblastoma-like osteosarcoma from osteoblastoma and aggressive osteoblastoma remains controversial and challenging. Previous studies suggest that these three types of tumor are distinct entities. However, working out a precise diagnosis may not always be possible immediately on the basis of initial clinical, radiological, and histopathological features. On the other hand, the importance of a correct diagnosis cannot be overemphasized since the treatment strategies change dramatically according to the nature of the lesion. In all of our cases, initial Tru-Cut biopsies revealed osteoblastic features with minimal atypia, but further biopsies confirmed malignancy. A high index of suspicion and considerable experience are prerequisites for accurate diagnosis in case of clinicopathological and radiological discordance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 2 | 11% |
Student > Bachelor | 2 | 11% |
Researcher | 2 | 11% |
Student > Master | 2 | 11% |
Librarian | 1 | 5% |
Other | 2 | 11% |
Unknown | 8 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 47% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Neuroscience | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Unknown | 7 | 37% |