| Title |
Toll-like receptors in the pathogenesis of autoimmune diseases: recent and emerging translational developments
|
|---|---|
| Published in |
ImmunoTargets and Therapy, August 2016
|
| DOI | 10.2147/itt.s89795 |
| Pubmed ID | |
| Authors |
Laura Duffy, Steven C O’Reilly |
| Abstract |
Autoinflammatory diseases are defined as the loss of self-tolerance in which an inflammatory response to self-antigens occurs, which are a significant global burden. Toll-like receptors are key pattern recognition receptors, which integrate signals leading to the activation of transcription factors and ultimately proinflammatory cytokines. Recently, it has become apparent that these are at the nexus of autoinflammatory diseases making them viable and attractive drug targets. The aim of this review was to evaluate the role of innate immunity in autoinflammatory conditions alongside the role of negative regulation while suggesting possible therapeutic targets. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ecuador | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 85 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 15% |
| Student > Master | 12 | 14% |
| Student > Bachelor | 10 | 12% |
| Researcher | 10 | 12% |
| Student > Postgraduate | 8 | 9% |
| Other | 13 | 15% |
| Unknown | 20 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 18 | 21% |
| Agricultural and Biological Sciences | 14 | 16% |
| Medicine and Dentistry | 13 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Neuroscience | 4 | 5% |
| Other | 6 | 7% |
| Unknown | 24 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2023.
All research outputs
#7,005,635
of 25,748,735 outputs
Outputs from ImmunoTargets and Therapy
#1
of 1 outputs
Outputs of similar age
#110,992
of 382,496 outputs
Outputs of similar age from ImmunoTargets and Therapy
#1
of 1 outputs
Altmetric has tracked 25,748,735 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1 research outputs from this source. They receive a mean Attention Score of 4.8. This one scored the same or higher as 0 of them.
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