| Title |
Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica
|
|---|---|
| Published in |
International Journal of Nanomedicine, November 2012
|
| DOI | 10.2147/ijn.s37650 |
| Pubmed ID | |
| Authors |
Zhouhua Wang, Bao Chen, Guilan Quan, Feng Li, Qiaoli Wu, Linghui Dian, Yixuan Dong, Ge Li, Chuanbin Wu |
| Abstract |
The aim of this study was to develop an immediate-release pellet formulation with improved drug dissolution and adsorption. Carbamazepine, a poorly water-soluble drug, was adsorbed into mesoporous silica (SBA-15-CBZ) via a wetness impregnation method and then processed by extrusion/spheronization into pellets. Physicochemical characterization of the preparation was carried out by scanning electron microscopy, transmission electron microscopy, nitrogen adsorption, small-angle and wide-angle x-ray diffraction, and differential scanning calorimetry. Flowability and wettability of the drug-loaded silica powder were evaluated by bulk and tapped density and by the angle of repose and contact angle, respectively. The drug-loaded silica powder was formulated into pellets to improve flowability. |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 100 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 20% |
| Researcher | 10 | 10% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Student > Bachelor | 5 | 5% |
| Other | 19 | 18% |
| Unknown | 33 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 18% |
| Chemistry | 12 | 12% |
| Materials Science | 10 | 10% |
| Chemical Engineering | 5 | 5% |
| Medicine and Dentistry | 3 | 3% |
| Other | 12 | 12% |
| Unknown | 42 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2022.
All research outputs
#5,339,559
of 25,374,917 outputs
Outputs from International Journal of Nanomedicine
#498
of 4,122 outputs
Outputs of similar age
#39,716
of 202,252 outputs
Outputs of similar age from International Journal of Nanomedicine
#8
of 51 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,252 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.