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MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance

Overview of attention for article published in International Journal of Nanomedicine, August 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
14 Mendeley
Title
MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance
Published in
International Journal of Nanomedicine, August 2016
DOI 10.2147/ijn.s114705
Pubmed ID
Authors

Salvatore Cannistraro, Ilaria Moscetti, Emanuela Teveroni, Fabiola Moretti, Anna Rita Bizzarri

Abstract

Murine double minute 2 (MDM2) and 4 (MDM4) are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2-MDM4 complex could be a target for promising therapeutic restoration of p53 function. To this aim, a deeper understanding of the molecular mechanisms underlining the heterodimerization is needed. The kinetic and thermodynamic characterization of the MDM2-MDM4 complex was performed with two complementary approaches: atomic force spectroscopy and surface plasmon resonance. Both techniques revealed an equilibrium dissociation constant (KD ) in the micromolar range for the MDM2-MDM4 heterodimer, similar to related complexes involved in the p53 network. Furthermore, the MDM2-MDM4 complex is characterized by a relatively high free energy, through a single energy barrier, and by a lifetime in the order of tens of seconds. New insights into the MDM2-MDM4 interaction could be highly important for developing innovative anticancer drugs focused on p53 reactivation.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 36%
Researcher 3 21%
Professor > Associate Professor 2 14%
Student > Master 1 7%
Professor 1 7%
Other 2 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 21%
Agricultural and Biological Sciences 2 14%
Computer Science 1 7%
Unspecified 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 5 36%
Unknown 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2016.
All research outputs
#3,814,674
of 8,307,635 outputs
Outputs from International Journal of Nanomedicine
#440
of 1,814 outputs
Outputs of similar age
#111,525
of 251,639 outputs
Outputs of similar age from International Journal of Nanomedicine
#41
of 138 outputs
Altmetric has tracked 8,307,635 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 1,814 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,639 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.