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Case of invasive nontypable Haemophilus influenzae respiratory tract infection with a large quantity of neutrophil extracellular traps in sputum

Overview of attention for article published in Journal of Inflammation Research, December 2012
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Mentioned by

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1 Facebook page
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1 Google+ user

Citations

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7 Dimensions

Readers on

mendeley
25 Mendeley
Title
Case of invasive nontypable Haemophilus influenzae respiratory tract infection with a large quantity of neutrophil extracellular traps in sputum
Published in
Journal of Inflammation Research, December 2012
DOI 10.2147/jir.s39497
Pubmed ID
Authors

Masafumi Seki, Hamaguch, Yamamoto, Hirose, Matsumoto, Irisawa, Takegawa, Shimazu, Tomono

Abstract

Haemophilus influenzae type b was once the most common cause of invasive H. influenzae infection, but the incidence of this disease has decreased markedly with introduction of conjugate vaccines to prevent the disease. In contrast, the incidence of invasive infection caused by nontypable H. influenzae has increased in the US and in European countries. Neutrophil extracellular traps (NETs) are fibrous structures released extracellularly from activated neutrophils during inflammation, including in pneumonia, and rapidly trap and kill pathogens as a first line of immunological defense. However, their function and pathological role have not been fully investigated. Here, we report a case of fatal nontypable H. influenzae infection with severe pneumonia and bacteremia in an adult found to have a vast amount of NETs in his sputum. The patient had a two-day history of common cold-like symptoms and was taken to the emergency room as a cardiopulmonary arrest. He recovered temporarily, but died soon afterwards, although appropriate antibiotic therapy and general management had been instituted. Massive lobular pneumonia and sepsis due to nontypable H. influenzae was found, in spite of H. influenzae type b vaccine being available. His sputum showed numerous bacteria phagocytosed by neutrophils, and immunohistological staining indicated a number of NETs containing DNA, histone H3, and neutrophil elastase. This case highlights an association between formation of NETs and severe respiratory and septic infection. An increase in severe nontypable H. influenzae disease can be expected as a result of "pathogen shift" due to increased use of the H. influenzae type b vaccine in Japan.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 16%
Student > Ph. D. Student 4 16%
Student > Doctoral Student 3 12%
Student > Master 3 12%
Professor 1 4%
Other 5 20%
Unknown 5 20%
Readers by discipline Count As %
Medicine and Dentistry 10 40%
Immunology and Microbiology 5 20%
Agricultural and Biological Sciences 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Unspecified 1 4%
Other 0 0%
Unknown 6 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2012.
All research outputs
#1,806,978
of 3,634,360 outputs
Outputs from Journal of Inflammation Research
#11
of 38 outputs
Outputs of similar age
#126,673
of 278,465 outputs
Outputs of similar age from Journal of Inflammation Research
#2
of 5 outputs
Altmetric has tracked 3,634,360 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 38 research outputs from this source. They receive a mean Attention Score of 1.5. This one scored the same or higher as 27 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,465 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.