| Title |
Dysfunctional lung anatomy and small airways degeneration in COPD
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, January 2013
|
| DOI | 10.2147/copd.s28290 |
| Pubmed ID | |
| Authors |
Clémence Martin, Justine Frija, Pierre-Régis Burgel |
| Abstract |
Chronic obstructive pulmonary disease (COPD) is characterized by incompletely reversible airflow obstruction. Direct measurement of airways resistance using invasive techniques has revealed that the site of obstruction is located in the small conducting airways, ie, bronchioles with a diameter < 2 mm. Anatomical changes in these airways include structural abnormalities of the conducting airways (eg, peribronchiolar fibrosis, mucus plugging) and loss of alveolar attachments due to emphysema, which result in destabilization of these airways related to reduced elastic recoil. The relative contribution of structural abnormalities in small conducting airways and emphysema has been a matter of much debate. The present article reviews anatomical changes and inflammatory mechanisms in small conducting airways and in the adjacent lung parenchyma, with a special focus on recent anatomical and imaging data suggesting that the initial event takes place in the small conducting airways and results in a dramatic reduction in the number of airways, together with a reduction in the cross-sectional area of remaining airways. Implications of these findings for the development of novel therapies are briefly discussed. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| India | 1 | <1% |
| Saudi Arabia | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 109 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 17% |
| Student > Bachelor | 17 | 15% |
| Researcher | 15 | 13% |
| Other | 13 | 11% |
| Student > Ph. D. Student | 9 | 8% |
| Other | 19 | 17% |
| Unknown | 22 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 47 | 41% |
| Agricultural and Biological Sciences | 13 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Nursing and Health Professions | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Other | 8 | 7% |
| Unknown | 29 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2013.
All research outputs
#16,721,208
of 25,371,288 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,613
of 2,577 outputs
Outputs of similar age
#187,791
of 288,986 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#10
of 15 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,577 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,986 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.