Title |
Profile of cabozantinib and its potential in the treatment of advanced medullary thyroid cancer
|
---|---|
Published in |
OncoTargets and therapy, January 2013
|
DOI | 10.2147/ott.s27671 |
Pubmed ID | |
Authors |
Christopher D Hart, Richard H De Boer |
Abstract |
Medullary thyroid cancer is an uncommon malignancy for which until recently little effective treatment existed. It is often characterized by mutation and overexpression of the receptor tyrosine kinases RET (rearranged during transfection), VEGFR2 (vascular endothelial growth factor receptor 2) and MET (mesenchymal-epithelial transition factor), which make attractive targets for drug development. Cabozantinib is an orally bioavailable tyrosine kinase inhibitor which blocks MET, VEGRF2 and RET, and has shown considerable activity in medullary thyroid cancer in a Phase III trial, including in heavily pretreated patients. Its novel combination of vascular endothelial growth factor and MET inhibition is believed to address the MET escape pathway, which is thought to be the cause of nonsustained tumor responses resulting from inhibition of vascular endothelial growth factor alone. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 20% |
Other | 5 | 17% |
Student > Master | 5 | 17% |
Student > Ph. D. Student | 3 | 10% |
Student > Bachelor | 1 | 3% |
Other | 5 | 17% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 43% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Agricultural and Biological Sciences | 3 | 10% |
Economics, Econometrics and Finance | 1 | 3% |
Chemistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 27% |