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Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities

Overview of attention for article published in Drug Design, Development and Therapy, September 2016
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Mentioned by

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2 tweeters

Citations

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Readers on

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7 Mendeley
Title
Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities
Published in
Drug Design, Development and Therapy, September 2016
DOI 10.2147/dddt.s111266
Pubmed ID
Authors

Pinki Rawat, Saurabh M Verma

Abstract

A series of chroman derivatives was designed, prepared, and examined for their anti-breast cancer and antiepileptic activities. All synthesized compounds yielded results that were in good agreement with spectral data. The bioassay showed that some of the resultant compounds exerted remarkable inhibitory effects on growth of human breast cancer cell line MCF-7. In particular, compound 6i (the concentration required for 50% inhibition of cell growth [GI50] =34.7 µM) exerted promising anticancer activity toward MCF-7 cell line. Additionally, compounds 6b, 6c, 6d, 6e, 6g, 6i, and 6l showed advanced antiepileptic activity than reference drugs. None of the compounds showed neurotoxicity, as determined by the rotarod test. The obtained results proved that these distinctive compounds could be relevant as models for future discovery and research, as well as for the production of more number of active derivatives.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 57%
Student > Ph. D. Student 1 14%
Student > Master 1 14%
Unknown 1 14%
Readers by discipline Count As %
Chemistry 3 43%
Medicine and Dentistry 2 29%
Agricultural and Biological Sciences 1 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2016.
All research outputs
#6,326,385
of 8,336,644 outputs
Outputs from Drug Design, Development and Therapy
#565
of 1,052 outputs
Outputs of similar age
#178,422
of 252,339 outputs
Outputs of similar age from Drug Design, Development and Therapy
#31
of 68 outputs
Altmetric has tracked 8,336,644 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,052 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,339 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.