Title |
Substance abuse, hepatitis C, and aging in HIV: common cofactors that contribute to neurobehavioral disturbances
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Published in |
Neurobehavioral HIV medicine, February 2012
|
DOI | 10.2147/nbhiv.s17408 |
Pubmed ID | |
Authors |
Randi Melissa Schuster, Raul Gonzalez |
Abstract |
Although the prevalence of neurocognitive disturbances among individuals with HIV has decreased in recent years, rates of impairment still remain high. This review presents findings from comorbid conditions that may contribute to further neurocognitive impairments in this already vulnerable population. We will focus on three co-factors that have received substantial attention in the neuroAIDS literature: drug use, hepatitis C co-infection (HCV), and aging. All three conditions commonly co-occur with HIV and likely interact with HIV in complex ways. Collectively, the extant literature suggests that drug use, HCV, and aging serve to worsen the neurocognitive profile of HIV through several overlapping mechanisms. A better understanding of how specific comorbidities interact with HIV may reveal specific phenotypes of HIV-associated neurocognitive disorder that may aid in the development of more targeted behavioral and pharmacological treatment efforts. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 18% |
Student > Ph. D. Student | 5 | 15% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 3 | 9% |
Other | 3 | 9% |
Other | 7 | 21% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
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Psychology | 3 | 9% |
Nursing and Health Professions | 3 | 9% |
Agricultural and Biological Sciences | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Other | 7 | 21% |
Unknown | 9 | 26% |