| Title |
3-Aminopropylsilane-modified iron oxide nanoparticles for contrast-enhanced magnetic resonance imaging of liver lesions induced by Opisthorchis felineus
|
|---|---|
| Published in |
International Journal of Nanomedicine, September 2016
|
| DOI | 10.2147/ijn.s111880 |
| Pubmed ID | |
| Authors |
Alexander M Demin, Alexandra G Pershina, Vladimir V Ivanov, Kseniya V Nevskaya, Oleg B Shevelev, Artyom S Minin, Iliya V Byzov, Alexey E Sazonov, Victor P Krasnov, Ludmila M Ogorodova |
| Abstract |
Liver fluke causes severe liver damage in an infected human. However, the infection often remains neglected due to the lack of pathognomonic signs. Nanoparticle-enhanced magnetic resonance imaging (MRI) offers a promising technique for detecting liver lesions induced by parasites. Surface modification of iron oxide nanoparticles produced by coprecipitation from a solution of Fe(3+) and Fe(2+) salts using 3-aminopropylsilane (APS) was carried out. The APS-modified nanoparticles were characterized by transmission electron microscopy, fourier transform infrared spectroscopy, and thermogravimetric analysis. Magnetic resonance properties of MNPs were investigated in vitro and in vivo. The amount of APS grafted on the surface of nanoparticles (0.60±0.06 mmol g(-1)) was calculated based on elemental analysis and infrared spectroscopy data. According to transmission electron microscopy data, there were no essential changes in the structure of nanoparticles during the modification. The APS-modified nanoparticles exhibit high magnetic properties; the calculated relaxivity r 2 was 271 mmol(-1) s(-1). To obtain suspension with optimal hydrodynamic characteristics, amino groups on the surface of nanoparticles were converted into an ionic form with HCl. Cellular uptake of modified nanoparticles by rat hepatoma cells and human monocytes in vitro was 74.1±4.5 and 10.0±3.7 pg [Fe] per cell, respectively. Low cytotoxicity of the nanoparticles was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Annexin V/7-aminoactinomycin D flow cytometry assays. For the first time, magnetic nanoparticles were applied for contrast-enhanced MRI of liver lesions induced by Opisthorchis felineus. The synthesized APS-modified iron oxide nanoparticles showed high efficiency as an MRI contrast agent for the evaluation of opisthorchiasis-related liver damage. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 16% |
| Student > Doctoral Student | 5 | 13% |
| Student > Bachelor | 4 | 11% |
| Student > Master | 4 | 11% |
| Student > Ph. D. Student | 3 | 8% |
| Other | 6 | 16% |
| Unknown | 10 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 24% |
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Chemical Engineering | 2 | 5% |
| Physics and Astronomy | 2 | 5% |
| Immunology and Microbiology | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 14 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2016.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from International Journal of Nanomedicine
#2,970
of 4,123 outputs
Outputs of similar age
#257,784
of 348,359 outputs
Outputs of similar age from International Journal of Nanomedicine
#118
of 128 outputs
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