Title |
Eribulin in the management of inoperable soft-tissue sarcoma: patient selection and survival
|
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Published in |
OncoTargets and therapy, September 2016
|
DOI | 10.2147/ott.s93517 |
Pubmed ID | |
Authors |
Colin Thomas, Sujana Movva |
Abstract |
Patients diagnosed with metastatic soft-tissue sarcoma (STS) have a poor prognosis. Additionally, after failure of first-line therapy, there are relatively few treatment options from which to choose. The novel tubulin-binding drug, eribulin, with a unique mechanism of action from taxanes or vinca alkaloids, has shown clinical activity in several different types of cancers. Eribulin has been approved by the US Food and Drug Administration (FDA) for patients with metastatic breast cancer previously treated with an anthracycline or a taxane and has recently been FDA approved for patients with unresectable or metastatic liposarcoma who have failed a previous anthracycline regimen. Here, we review current standard treatments of STS, a background of eribulin, the studies that have propelled eribulin to FDA approval for liposarcoma, and future directions of the drug. The benefits of eribulin in STS are discussed in detail, especially with regard to the recent pivotal Phase III study comparing eribulin to dacarbazine for leiomyosarcoma and adipocytic sarcoma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 4 | 16% |
Student > Ph. D. Student | 4 | 16% |
Student > Bachelor | 3 | 12% |
Lecturer | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 4 | 16% |
Unknown | 6 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 28% |
Agricultural and Biological Sciences | 4 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Business, Management and Accounting | 1 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 2 | 8% |
Unknown | 7 | 28% |