Title |
Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease
|
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Published in |
International Journal of Chronic Obstructive Pulmonary Disease, September 2016
|
DOI | 10.2147/copd.s107844 |
Pubmed ID | |
Authors |
Makedonka Gulcev, Cavan Reilly, Timothy J Griffin, Corey D Broeckling, Brian J Sandri, Bruce A Witthuhn, Shane W Hodgson, Prescott G Woodruff, Chris H Wendt |
Abstract |
Exacerbations are a leading cause of morbidity in COPD. The objective of this study was to identify metabolomic biomarkers of acute exacerbations of COPD (AECOPD). We measured metabolites via mass spectrometry (MS) in plasma drawn within 24 hours of admission to the hospital for 33 patients with an AECOPD (day 0) and 30 days later and for 65 matched controls. Individual metabolites were measured via selective reaction monitoring with mass spectrometry. We used a mixed-effect model to compare metabolite levels in cases compared to controls and a paired t-test to test for differences between days 0 and 30 in the AECOPD group. We identified 377 analytes at a false discovery rate of 5% that differed between cases (day 0) and controls, and 31 analytes that differed in the AECOPD cases between day 0 and day 30 (false discovery rate: 5%). Tryptophan was decreased at day 0 of AECOPD compared to controls corresponding to an increase in indoleamine 2,3-dioxygenase activity. Patients with AECOPD have a unique metabolomic signature that includes a decrease in tryptophan levels consistent with an increase in indoleamine 2,3-dioxygenase activity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
United Kingdom | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 18% |
Researcher | 4 | 14% |
Other | 3 | 11% |
Student > Bachelor | 2 | 7% |
Student > Ph. D. Student | 2 | 7% |
Other | 4 | 14% |
Unknown | 8 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 39% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Computer Science | 2 | 7% |
Agricultural and Biological Sciences | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 1 | 4% |
Unknown | 9 | 32% |