| Title |
Personality features, dissociation, self-stigma, hope, and the complex treatment of depressive disorder
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, October 2016
|
| DOI | 10.2147/ndt.s117037 |
| Pubmed ID | |
| Authors |
Jan Prasko, Marie Ociskova, Ales Grambal, Zuzana Sigmundova, Petra Kasalova, Marketa Marackova, Michaela Holubova, Kristyna Vrbova, Klara Latalova, Milos Slepecky |
| Abstract |
Identifying the predictors of response to psychiatric and psychotherapeutic treatments may be useful for increasing treatment efficacy in pharmacoresistant depressive patients. The goal of this study was to examine the influence of dissociation, hope, personality trait, and selected demographic factors in treatment response of this group of patients. Pharmacoresistant depressive inpatients were enrolled in the study. All patients completed Clinical Global Impression - both objective and subjective form (CGI), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) at baseline and after 6 weeks of combined pharmacotherapy and psychotherapy (group cognitive-behavioral or group psychodynamic) treatment as an outcome measures. The Internalized Stigma of Mental Illness Scale (ISMI), Dissociative Experience Scale (DES), Adult Dispositional Hope Scale (ADHS), and Temperament and Character Inventory (TCI-R) were completed at the start of the treatment with the intention to find the predictors of treatment efficacy. The study included 72 patients who were hospitalized for the pharmacoresistant major depression; 63 of them completed the study. The mean scores of BDI-II, BAI, subjCGI, and objCGI significantly decreased during the treatment. BDI-II relative change statistically significantly correlated with the total ISMI score, Discrimination Experience (ISMI subscale), and Harm Avoidance (TCI-R personality trait). According to stepwise regression, the strongest factors connected to BDI-II relative change were the duration of the disorder and Discrimination Experience (domain of ISMI). ObjCGI relative change significantly correlated with the level of dissociation (DES), the total ISMI score, hope in ADHS total score, and Self-Directedness (TCI-R). According to stepwise regression, the strongest factor connected to objCGI relative change was Discrimination Experience (domain of ISMI). The existence of comorbid personality disorder did not influence the treatment response. According to the results of the present study, patients with pharmacoresistant depressive disorders, who have had more experience with discrimination because of their mental struggles, showed a poorer response to treatment. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| Unknown | 101 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 12% |
| Student > Ph. D. Student | 11 | 11% |
| Researcher | 10 | 10% |
| Student > Bachelor | 10 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 21 | 21% |
| Unknown | 32 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 40 | 39% |
| Medicine and Dentistry | 11 | 11% |
| Social Sciences | 6 | 6% |
| Computer Science | 2 | 2% |
| Nursing and Health Professions | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 34 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2016.
All research outputs
#17,438,425
of 25,582,611 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,869
of 3,120 outputs
Outputs of similar age
#217,264
of 333,142 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#52
of 85 outputs
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