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Increased survival rate by local release of diclofenac in a murine model of recurrent oral carcinoma

Overview of attention for article published in International Journal of Nanomedicine, October 2016
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

twitter
3 tweeters

Citations

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7 Dimensions

Readers on

mendeley
20 Mendeley
Title
Increased survival rate by local release of diclofenac in a murine model of recurrent oral carcinoma
Published in
International Journal of Nanomedicine, October 2016
DOI 10.2147/ijn.s109199
Pubmed ID
Authors

Olga Maria Will, N Purcz, Athena Chalaris, Carola Heneweer, Susann Boretius, Larissa Purcz, Lila Nikkola, Nureddin Ashammakhi, Holger Kalthoff, Claus-Christian Glüer, Jörg Wiltfang, Yahya Açil, Sanjay Tiwari

Abstract

Despite aggressive treatment with radiation and combination chemotherapy following tumor resection, the 5-year survival rate for patients with head and neck cancer is at best only 50%. In this study, we examined the therapeutic potential of localized release of diclofenac from electrospun nanofibers generated from poly(D,L-lactide-co-glycolide) polymer. Diclofenac was chosen since anti-inflammatory agents that inhibit cyclooxygenase have shown great potential in their ability to directly inhibit tumor growth as well as suppress inflammation-mediated tumor growth. A mouse resection model of oral carcinoma was developed by establishing tumor growth in the oral cavity by ultrasound-guided injection of 1 million SCC-9 cells in the floor of the mouth. Following resection, mice were allocated into four groups with the following treatment: 1) no treatment, 2) implanted scaffolds without diclofenac, 3) implanted scaffolds loaded with diclofenac, and 4) diclofenac given orally. Small animal ultrasound and magnetic resonance imaging were utilized for longitudinal determination of tumor recurrence. At the end of 7 weeks following tumor resection, 33% of mice with diclofenac-loaded scaffolds had a recurrent tumor, in comparison to 90%-100% of the mice in the other three groups. At this time point, mice with diclofenac-releasing scaffolds showed 89% survival rate, while the other groups showed survival rates of 10%-25%. Immunohistochemical staining of recurrent tumors revealed a near 10-fold decrease in the proliferation marker Ki-67 in the tumors derived from mice with diclofenac-releasing scaffolds. In summary, the local application of diclofenac in an orthotopic mouse tumor resection model of oral cancer reduced tumor recurrence with significant improvement in survival over a 7-week study period following tumor resection. Local drug release of anti-inflammatory agents should be investigated as a therapeutic option in the prevention of tumor recurrence in oral squamous carcinoma.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 20%
Professor > Associate Professor 2 10%
Student > Bachelor 2 10%
Student > Postgraduate 2 10%
Student > Ph. D. Student 2 10%
Other 4 20%
Unknown 4 20%
Readers by discipline Count As %
Medicine and Dentistry 7 35%
Chemistry 3 15%
Agricultural and Biological Sciences 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 0 0%
Unknown 7 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2017.
All research outputs
#4,423,062
of 9,140,924 outputs
Outputs from International Journal of Nanomedicine
#588
of 1,992 outputs
Outputs of similar age
#120,707
of 256,294 outputs
Outputs of similar age from International Journal of Nanomedicine
#36
of 110 outputs
Altmetric has tracked 9,140,924 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,992 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,294 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.