| Title |
Chronotropic incompetence can limit exercise tolerance in COPD patients with lung hyperinflation
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, October 2016
|
| DOI | 10.2147/copd.s112490 |
| Pubmed ID | |
| Authors |
Sébastien Hulo, Jocelyn Inamo, Aurélie Dehon, Olivier Le Rouzic, Jean-Louis Edme, Remi Neviere |
| Abstract |
Metabolic-chronotropic relationship is the only concept that assesses the entire chronotropic function during exercise, as it takes into account individual fitness. To better understand interrelationships between chronotropic incompetence (CI), dynamic hyperinflation (DH) and exercise limitation among Global initiative for chronic Obstructive Lung Disease (GOLD) stages of chronic obstructive pulmonary disease (COPD) disease severity, we evaluated cardiopulmonary responses to symptom-limited cycle exercise in stable patients. We prospectively studied 47 COPD patients classified by GOLD stage severity. Pulmonary function tests and cardiopulmonary responses to symptom-limited incremental exercise were studied. CI was defined by regression line between percent heart rate (HR) reserve and percent oxygen uptake (V'O2) reserve, ie, chronotropic-metabolic index (CMI). DH was defined from the knot resulting from the nonlinear regressions of inspiratory capacity changes from rest to peak (dynamic inspiratory capacity (ICdyn)) with percentage of maximal HR and CMI. Aerobic capacity (median interquartile ranges) peak V'O2, 24.3 (23.6; 25.2), 18.5 (15.5; 21.8), 17.5 (15.4; 19.1) mL·kg(-1)·min(-1) and CMI worsened according to GOLD severity. The optimal knot of ICdyn was equal to -0.34 L. The multivariate logistic regression showed a strong relationship between CI (outcome) and DH (odds ratio [confidence interval 95]) 25 (3.5; 191.6). COPD patients with DH have a poor cardiovascular response to exercise, which may be attributed to CI. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 15% |
| Researcher | 4 | 12% |
| Other | 3 | 9% |
| Student > Doctoral Student | 2 | 6% |
| Lecturer | 2 | 6% |
| Other | 7 | 21% |
| Unknown | 10 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 6 | 18% |
| Medicine and Dentistry | 4 | 12% |
| Mathematics | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Psychology | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 17 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2016.
All research outputs
#15,740,505
of 25,374,917 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,421
of 2,577 outputs
Outputs of similar age
#191,569
of 332,577 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#65
of 96 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,577 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
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