| Title |
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier
|
|---|---|
| Published in |
International Journal of Nanomedicine, October 2016
|
| DOI | 10.2147/ijn.s117210 |
| Pubmed ID | |
| Authors |
Débora B Vieira, Lionel F Gamarra |
| Abstract |
This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood-brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer's, Parkinson's, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood-brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 6 | 19% |
| United Kingdom | 2 | 6% |
| Solomon Islands | 1 | 3% |
| United States | 1 | 3% |
| France | 1 | 3% |
| Unknown | 21 | 66% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 88% |
| Practitioners (doctors, other healthcare professionals) | 3 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 585 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 585 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 89 | 15% |
| Student > Bachelor | 81 | 14% |
| Student > Master | 78 | 13% |
| Researcher | 58 | 10% |
| Student > Doctoral Student | 33 | 6% |
| Other | 71 | 12% |
| Unknown | 175 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 90 | 15% |
| Biochemistry, Genetics and Molecular Biology | 63 | 11% |
| Chemistry | 55 | 9% |
| Medicine and Dentistry | 41 | 7% |
| Agricultural and Biological Sciences | 37 | 6% |
| Other | 100 | 17% |
| Unknown | 199 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2023.
All research outputs
#1,061,629
of 25,848,962 outputs
Outputs from International Journal of Nanomedicine
#36
of 4,155 outputs
Outputs of similar age
#19,230
of 334,030 outputs
Outputs of similar age from International Journal of Nanomedicine
#2
of 109 outputs
Altmetric has tracked 25,848,962 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,155 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.