| Title |
Intravitreal bevacizumab injections for diabetic macular edema – predictors of response: a retrospective study
|
|---|---|
| Published in |
Clinical Ophthalmology, October 2016
|
| DOI | 10.2147/opth.s109809 |
| Pubmed ID | |
| Authors |
Lavnish Joshi, Asaf Bar, Oren Tomkins-Netzer, Satish Yaganti, Jiten Morarji, Panayiotis Vouzounis, Sophie Seguin-Greenstein, Simon R Taylor, Sue Lightman |
| Abstract |
Outcomes of intravitreal antivascular endothelial growth factor injections are variable among patients with diabetic macular edema (DME). The aim of this study was to determine the ocular and systemic predictors of DME response to intravitreal bevacizumab (IVB). Retrospective review over 2 years of 78 eyes from 54 patients. An anatomical response to IVB was defined as a 20% reduction in central macula thickness after the first course (three injections) of IVB. Twenty-eight percent of patients had an anatomical response after the first course of IVB. Systemic hypertension (odds ratio, 95% confidence interval: 12.1, 0.7-21) was a statistically significant predictor (P=0.025) of a good response to IVB, whereas previous macular laser was a statistically significant (P=0.0005) predictor of a poor response (0.07, 0.01-0.32). Sixty-eight percent of eyes underwent subsequent treatment for DME after the first course of IVB. The visual acuity gain at 24 months in hypertensive (0.7±3.6 letters) and nonhypertensive (5.2±3.7 letters) patients was not significantly different (P=0.41). Hypertension and previous macular laser were positive and negative predictors of response to IVB, respectively. However, long-term visual acuity changes were not significantly different between eyes with and without systemic hypertension. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 15% |
| Lecturer > Senior Lecturer | 3 | 12% |
| Student > Postgraduate | 3 | 12% |
| Student > Bachelor | 2 | 8% |
| Other | 2 | 8% |
| Other | 5 | 19% |
| Unknown | 7 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 58% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Computer Science | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Unknown | 8 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2017.
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#19,942,887
of 25,371,288 outputs
Outputs from Clinical Ophthalmology
#2,475
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#244,256
of 332,555 outputs
Outputs of similar age from Clinical Ophthalmology
#44
of 72 outputs
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