Title |
A patient previously treated with ALK inhibitors for central nervous system lesions from ALK rearranged lung cancer: a case report
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Published in |
OncoTargets and therapy, October 2016
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DOI | 10.2147/ott.s112833 |
Pubmed ID | |
Authors |
Jumpei Kashima, Yusuke Okuma, Tsunekazu Hishima |
Abstract |
Patients with anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) are now preferentially treated with tyrosine kinase inhibitors (TKIs). However, patients treated with ALK inhibitors end up with acquired resistance. We present a patient with recurrent ALK-rearranged NSCLC that developed multiple brain metastases and meningitis carcinomatosa after sequential treatment with several lines of cytotoxic chemotherapy, crizotinib, and alectinib. After the patient underwent retreatment with crizotinib as salvage therapy because of poor performance status, the intracranial metastatic foci and meningeal thickening were shrank within 1 week. Our experience with this case suggests that alectinib may restore sensitivity to crizotinib or amplified pathway such as MET which bestowed alectinib resistance was inhibited with crizotinib. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 22% |
Researcher | 3 | 17% |
Student > Bachelor | 3 | 17% |
Unspecified | 1 | 6% |
Other | 1 | 6% |
Other | 2 | 11% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 50% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Neuroscience | 1 | 6% |
Unspecified | 1 | 6% |
Unknown | 5 | 28% |