Title |
Effect of acetazolamide for long-lasting paroxysmal dystonia in a patient with multiple sclerosis: a case report and review of literature
|
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Published in |
Neuropsychiatric Disease and Treatment, April 2013
|
DOI | 10.2147/ndt.s43688 |
Pubmed ID | |
Authors |
Pei-Chun Hsieh, Shu-Min Chen, Yao-Hong Guo, Ta-Shen Kuan, Wei-Jang Yen, Wen-Chen Chang, Yu-Ching Lin |
Abstract |
Dystonia is a rare manifestation of multiple sclerosis (MS), but it always interferes with the functional performance and quality of life. We report a rare case of long-lasting paroxysmal dystonia associated with MS. The patient was a 40-year-old woman with relapsing- remitting MS for 6 years. During the latest attack of MS, she suffered from long-lasting paroxysmal dystonia in her left hand. Despite treatment with pulse high-dose intravenous methylprednisolone, interferon, and baclofen, along with occupational therapy, the dystonia persisted and significantly bothered her daily activities. Finally, she was treated with oral acetazolamide (250 mg, three times a day for 4 days), which was very effective for the control of her dystonia. The dystonic movement subsided without recurrence in a follow-up of 17 months. We advocate this effective and safe treatment for patients with paroxysmal dystonia associated with MS. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 28% |
Student > Ph. D. Student | 5 | 14% |
Other | 4 | 11% |
Student > Doctoral Student | 2 | 6% |
Student > Master | 2 | 6% |
Other | 5 | 14% |
Unknown | 8 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 28% |
Neuroscience | 6 | 17% |
Nursing and Health Professions | 5 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Other | 2 | 6% |
Unknown | 9 | 25% |