| Title |
Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study
|
|---|---|
| Published in |
International Journal of Nanomedicine, November 2011
|
| DOI | 10.2147/ijn.s25791 |
| Pubmed ID | |
| Authors |
Alyaa Ramadan, Frederic Lagarce, Anne Tessier-Marteau, Olivier Thomas, Pierre Legras, Laurent Macchi, Patrick Saulnier, Jean Pierre Benoit |
| Abstract |
Oral anticoagulant therapy could be advanced using lipid-based nanoparticulate systems. This study examined lipid nanocapsules for their oral absorption potential as the first step in developing oral fondaparinux (Fp) novel carriers. Using phase inversion method and cationic surfactants such as hexadecyltrimethyl ammonium bromide (CTAB) or stearylamine (SA), cationic lipid nanocapsules (cLNCs), loaded with Fp on their surface, were prepared and characterized (zeta potential, size and Fp association efficiency and content). In vivo studies were conducted after single oral increasing doses of Fp-loaded cLNCs (0.5 to 5 mg/kg of Fp) in rats and the concentration of Fp in the plasma was measured by anti-factor Xa activity assay. The monodisperse, (~50 nm), positively charged Fp-cLNCs with high drug loadings demonstrated linear pharmacokinetic profiles of the drug with an increased oral absolute bioavailability (up to ~21%) compatible with therapeutic anticoagulant effect (>0.2 μg/mL). |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 3% |
| Unknown | 31 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 6% |
| Student > Ph. D. Student | 2 | 6% |
| Student > Master | 2 | 6% |
| Student > Bachelor | 1 | 3% |
| Professor > Associate Professor | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 24 | 75% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 16% |
| Medicine and Dentistry | 2 | 6% |
| Engineering | 1 | 3% |
| Unknown | 24 | 75% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2011.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#3,598
of 4,123 outputs
Outputs of similar age
#141,473
of 153,810 outputs
Outputs of similar age from International Journal of Nanomedicine
#51
of 59 outputs
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We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.