"Ritonavir’s mechanisms of action include inhibition of the proteasome; inhibition of heat shock protein 90 (HSP90), cytochrome P450 3A4 (CYP3A4), and P-glycoprotein;" https://t.co/e8HkWk0A0w

https://t.co/MgS6q2vLbv "Ritonavir is thus thought to enhance tumor immunity and act against cancer by increasing the number of CD4+ T cells."

https://t.co/MgS6q2vLbv "CD4+ T cells are important in tumor immunity because they are needed to sustain the cytolytic CD8+ T cells, which can kill cancer cells, and because they recruit cells of the innate immune system, such as macrophages and mast cell

https://t.co/MgS6q2vLbv "Similarly, Sloand et al showed that ritonavir decreases CD4+ T-cell apoptosis by inhibiting caspase 1 expression independent of HIV infection, which could increase the number of CD4+ T cells."

https://t.co/MgS6q2vLbv "Weichold et al found that it increases the viability of peripheral blood mononuclear cells, decreases their susceptibility to apoptosis, and decreases their production of tumor necrosis factor."

https://t.co/MgS6q2vLbv "Interestingly, ritonavir has also been shown to increase lymphocyte levels itself."

https://t.co/MgS6q2vLbv "Ritonavir may also act against malignancies by enhancing immune system activity." "Ritonavir acts against acquired immunodeficiency syndrome by decreasing plasma viremia and thereby increasing CD4+ T-cell counts."

https://t.co/MgS6q2vLbv "whereas inhibition of CYP3A4 and P-glycoprotein increases the intracellular concentration of other drugs."

https://t.co/MgS6q2vLbv "and modulation of immune system activity. Inhibition of the proteasome and HSP90 causes unfolded proteins to accumulate and thereby induces endoplasmic reticulum (ER) stress,"

https://t.co/MgS6q2vLbv "Ritonavir’s mechanisms of action include inhibition of the proteasome; inhibition of heat shock protein 90 (HSP90), cytochrome P450 3A4 (CYP3A4), and P-glycoprotein;"

The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies #MECFS #LongCovid https://t.co/MgS6q2vLbv