https://t.co/W2uut1jjoe "SOCS3 is a feedback inhibitor of the JAK–STAT3 pathway."
https://t.co/W2uut1jjoe "in macrophages treated with CCL5, increased levels of SOCS3 were abrogated by the blockage of the CCL5–CCR5 axis with MVC (Maraviroc), thereby leading to increased STAT3 levels typically linked to an M1-polarized state."
https://t.co/W2uut1jjoe "The CCL5–CCR5 axis modulates macrophage polarization through the STAT3–SOCS3 pathway."
Blocking the CCL5–CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells https://t.co/W2uut1jjoe "M2 polarization of macrophages induced by CCL5–CCR5 signaling can be inhibited using MVC via the STAT3–