| Title |
Comparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels
|
|---|---|
| Published in |
Journal of Pain Research, March 2013
|
| DOI | 10.2147/jpr.s41614 |
| Pubmed ID | |
| Authors |
Hiroshi Nakagawa, Akio Hiura |
| Abstract |
It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin is problematic in therapeutic use because it induces firing of nociceptors. The present study aimed to search for substitutes for capsaicin. We also examined the transportability of QX-314 into nociceptive neurons, through the pores of transient receptor potential ankyrin 1 (TRPA1), transient receptor potential melastatin-8 (TRPM8), and TRPV1. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 23% |
| Researcher | 6 | 20% |
| Student > Bachelor | 3 | 10% |
| Other | 2 | 7% |
| Professor | 2 | 7% |
| Other | 4 | 13% |
| Unknown | 6 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 23% |
| Medicine and Dentistry | 6 | 20% |
| Neuroscience | 6 | 20% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Chemistry | 2 | 7% |
| Other | 0 | 0% |
| Unknown | 6 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2013.
All research outputs
#20,823,121
of 25,584,565 outputs
Outputs from Journal of Pain Research
#1,572
of 1,969 outputs
Outputs of similar age
#159,453
of 206,591 outputs
Outputs of similar age from Journal of Pain Research
#16
of 22 outputs
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