Title |
Effect of image-guided hypofractionated stereotactic radiotherapy on peripheral non-small-cell lung cancer
|
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Published in |
OncoTargets and therapy, August 2016
|
DOI | 10.2147/ott.s101125 |
Pubmed ID | |
Authors |
Shu-wen Wang, Juan Ren, Yan-li Yan, Chao-fan Xue, Li Tan, Xiao-wei Ma |
Abstract |
The objective of this study was to compare the effects of image-guided hypofractionated radiotherapy and conventional fractionated radiotherapy on non-small-cell lung cancer (NSCLC). Fifty stage- and age-matched cases with NSCLC were randomly divided into two groups (A and B). There were 23 cases in group A and 27 cases in group B. Image-guided radiotherapy (IGRT) and stereotactic radiotherapy were conjugately applied to the patients in group A. Group A patients underwent hypofractionated radiotherapy (6-8 Gy/time) three times per week, with a total dose of 64-66 Gy; group B received conventional fractionated radiotherapy, with a total dose of 68-70 Gy five times per week. In group A, 1-year and 2-year local failure survival rate and 1-year local failure-free survival rate were significantly higher than in group B (P<0.05). The local failure rate (P<0.05) and distant metastasis rate (P>0.05) were lower in group A than in group B. The overall survival rate of group A was significantly higher than that of group B (P=0.03), and the survival rate at 1 year was 87% vs 63%, (P<0.05). The median survival time of group A was longer than that of group B. There was no significant difference in the incidence of complications between the two groups (P>0.05). Compared with conventional fractionated radiation therapy, image-guided hypofractionated stereotactic radiotherapy in NSCLC received better treatment efficacy and showed good tolerability. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 19% |
Student > Master | 3 | 19% |
Student > Ph. D. Student | 2 | 13% |
Student > Bachelor | 2 | 13% |
Researcher | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 31% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Nursing and Health Professions | 2 | 13% |
Psychology | 1 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Other | 2 | 13% |
Unknown | 3 | 19% |