Title |
Role of pharmacogenomics in the treatment of tuberculosis: a review
|
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Published in |
Pharmacogenomics and Personalized Medicine, September 2012
|
DOI | 10.2147/pgpm.s15454 |
Pubmed ID | |
Authors |
Geetha Ramachandran, Soumya Swaminathan |
Abstract |
Tuberculosis is one of the major public health problems worldwide. Modern antituberculous treatment can cure most patients; cure rates > 95% are achieved with standard short-course chemotherapy regimens containing isoniazid, rifampicin, pyrazinamide, and ethambutol among patients with drug-susceptible strains of tuberculosis; however, a small proportion do not respond to treatment or develop serious adverse events. Pharmacogenomic studies of drugs used in the treatment of tuberculosis could help us understand intersubject variations in treatment response. In this review, we compiled pharmacogenomic data on antituberculous drugs that were available from different settings that would give a better insight into the role of pharmacogenomics in the treatment of tuberculosis, thereby enhancing the efficacy and limiting the toxicity of existing antituberculosis medications. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 2 | 1% |
Finland | 1 | <1% |
India | 1 | <1% |
Egypt | 1 | <1% |
Unknown | 176 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 32 | 18% |
Researcher | 23 | 13% |
Student > Bachelor | 21 | 12% |
Student > Ph. D. Student | 15 | 8% |
Student > Postgraduate | 9 | 5% |
Other | 30 | 17% |
Unknown | 51 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 27 | 15% |
Agricultural and Biological Sciences | 22 | 12% |
Biochemistry, Genetics and Molecular Biology | 21 | 12% |
Immunology and Microbiology | 9 | 5% |
Other | 14 | 8% |
Unknown | 52 | 29% |