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Role of pharmacogenomics in the treatment of tuberculosis: a review

Overview of attention for article published in Pharmacogenomics and Personalized Medicine, April 2013
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Title
Role of pharmacogenomics in the treatment of tuberculosis: a review
Published in
Pharmacogenomics and Personalized Medicine, April 2013
DOI 10.2147/pgpm.s15454
Pubmed ID
Authors

Geetha Ramachandran, Soumya Swaminathan

Abstract

Tuberculosis is one of the major public health problems worldwide. Modern antituberculous treatment can cure most patients; cure rates > 95% are achieved with standard short-course chemotherapy regimens containing isoniazid, rifampicin, pyrazinamide, and ethambutol among patients with drug-susceptible strains of tuberculosis; however, a small proportion do not respond to treatment or develop serious adverse events. Pharmacogenomic studies of drugs used in the treatment of tuberculosis could help us understand intersubject variations in treatment response. In this review, we compiled pharmacogenomic data on antituberculous drugs that were available from different settings that would give a better insight into the role of pharmacogenomics in the treatment of tuberculosis, thereby enhancing the efficacy and limiting the toxicity of existing antituberculosis medications.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 2 1%
Finland 1 <1%
India 1 <1%
Egypt 1 <1%
Unknown 155 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 30 19%
Researcher 20 13%
Student > Bachelor 19 12%
Student > Ph. D. Student 16 10%
Student > Postgraduate 8 5%
Other 29 18%
Unknown 38 24%
Readers by discipline Count As %
Medicine and Dentistry 36 23%
Pharmacology, Toxicology and Pharmaceutical Science 26 16%
Biochemistry, Genetics and Molecular Biology 21 13%
Agricultural and Biological Sciences 21 13%
Immunology and Microbiology 8 5%
Other 10 6%
Unknown 38 24%