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Preparation and characterization of novel chitosan-protamine nanoparticles for nucleus-targeted anticancer drug delivery

Overview of attention for article published in International Journal of Nanomedicine, November 2016
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1 tweeter

Citations

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17 Mendeley
Title
Preparation and characterization of novel chitosan-protamine nanoparticles for nucleus-targeted anticancer drug delivery
Published in
International Journal of Nanomedicine, November 2016
DOI 10.2147/ijn.s117066
Pubmed ID
Authors

Xiwei Yu, Jiahui Hou, Yijie Shi, Chang Su, Liang Zhao

Abstract

It is well known that most anticancer drugs commonly show high toxicity to the DNA of tumor cells and exert effects by combining with the DNA or associated enzymes in the nucleus. Most developed drugs are first delivered into the cytoplasm and then transferred to the nucleus through the membrane pores. Sometimes, the transportation of drugs from cytoplasm to nucleus is not efficient and often results in poor therapeutic effects. In this study, we developed special and novel nanoparticles (NPs) made of chitosan and protamine for targeted nuclear capture of drugs to enhance anticancer effects. The anticancer effects of nuclear targeted-delivery of drugs in NPs were also evaluated by investigating cytotoxicity, cellular uptake mechanism, and cell apoptosis on cells. Chitosan-protamine NPs were characterized by good drug entrapment, sustained release, small average particle size, low polydispersity index, and high encapsulation efficiency; and accomplished the efficient nuclear delivery of fluorouracil (5-Fu). Compared with free 5-Fu and 5-Fu-loaded chitosan NPs, treatment of A549 cells and HeLa cells with 5-Fu-loaded chitosan-protamine NPs showed the highest cytotoxicity and further induced the significant apoptosis of cells. In addition, 5-Fu-loaded chitosan-protamine NPs exhibited the best efficiency in inhibiting tumor growth than the other three formulations. 5-Fu-loaded chitosan-protamine NPs enhanced antitumor efficacy through the targeted nuclear capture of drugs and showed promising potential as a nanodelivery system for quickly locating drugs in the nucleus of cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 24%
Student > Master 3 18%
Student > Postgraduate 2 12%
Student > Ph. D. Student 2 12%
Student > Bachelor 2 12%
Other 2 12%
Unknown 2 12%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 5 29%
Medicine and Dentistry 3 18%
Biochemistry, Genetics and Molecular Biology 2 12%
Chemistry 2 12%
Computer Science 1 6%
Other 3 18%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2016.
All research outputs
#6,603,322
of 8,670,160 outputs
Outputs from International Journal of Nanomedicine
#1,440
of 1,904 outputs
Outputs of similar age
#204,102
of 296,426 outputs
Outputs of similar age from International Journal of Nanomedicine
#67
of 95 outputs
Altmetric has tracked 8,670,160 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,904 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,426 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.